Objective
Aurora protein kinases belong to the family of serine/threonine protein kinases. They are evolutionarily conserved enzymes that regulate different aspects of cell division. In vertebrates, there exists three Aurora kinases namely, Aurora A, Aurora B and Aurora C. In contrast, the C. elegans and D. melanogaster genomes encode only for two Aurora orthologues, and the S. cerevisiae genome for a single one. Aurora kinases differ in length and sequence of the amino terminal domain (non-catalytic domain), but show considerable similarity in the carboxy-terminal catalytic domain. Interestingly, even in the presence of high sequence similarity the three Aurora kinases are localized in distinct locations and perform different functions.
Aurora A is shown to play a major role in centrosome separation, centrosome maturation and in the stabilization of mitotic spindle assembly, while the Aurora B is important in the regulation of kinetochore-microtubule interactions. The function of Aurora A is conserved in human, Xenopus, Drosophila and C. elegans. Recent studies that include the crystallographic studies from the host laboratory showed the role of TPX2, an activator of human Aurora A in molecular recognition and regulation. Although the function of Aurora A is con served in human, Xenopus, Drosophila and C. elegans, there is no apparent homologue of TPX2 in their respective genomes. In a similar note, the Auroras A and B share very high sequence identity but their respective activators TPX2 and INCENP do not show a ny reasonable sequence similarity.
The proposed project aims to understand the molecular machanism involved in the activation and regulation of Aurora A from C.elegans and Drosophila and of human Aurora B mainly using X-ray crystallographic methods. Since, Aurora proteins are oncogens, the structural information derived from this study would help in designing specific inhibitors to block their activation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-7
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
BANGALORE
India
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