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PRRS : EPIDEMIOLOGY AND CONTROL (WITH EMPHASIS ON DIAGNOSIC, VIRAL PERSISTENCE, EXTENT OF VIRAL DIVERSITY, ANTI-VIRAL IMMUNITY, AND MODES OF TRANSMISSION)

Objective



Objectives:
a) Establish a serum bank of seropositive field sera, originating from various regions of the EC, to provide valuable material for validating any future test and also allow examination of different isolates for serotypic variation: collection of serum from animals that have recovered from Porcine Reproductive and Respiratory Syndrom (PRRS), screening for antibody titres in sera of well described breeding and fattering herds.
b) Prepare a collection of primary isolates, originating from various regions of the EC. Of the Artiriviridae EAV and SHFV, it is known that various biotypes exist which vary in virulence and in the tendency to cause persistent infection. Therefore, it is important to isolate virus from cases where the method of transmission is unknown. Furthermore, the isolates need to be catalogued and stored under appropriate conditions, including freeze- drying of archive material.
c) Study the presence and distribution of Lelystad virus in meat and other pig organs: virus isolation and immuno-histochemical studies on tissue of experimentally infected pigs to investigated the route of infection and the presence of the virus.
d) In the future, assuming monoclonal antibody panels become established, hold a workshop to compare reactivities and assemble an EC panel for differentiation. That the virus will ultimately be sequenced, whereupon comparison and exchange of oligonucleoitide primers would prove valuable.

Funding Scheme

CON - Coordination of research actions

Coordinator

DLO - CENTRAAL DIERENGENEESKUNDIG INSTITUUT
Address
P.o. Box 365
8200 AJ Lelystad
Netherlands

Participants (6)

FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH
Germany
Address
Boddenblick 5 A
17498 Insel Riems
LABORATORIO DE SANIDAD Y PRODUCCION ANIMAL
Spain
Address

8001 Barcelona
MAFF Central Veterinary Laboratory
United Kingdom
Address
Woodham Lane New Haw Addlestone
KT15 3NB Weybridge
RIJKSUNIVERSITEIT GENT
Belgium
Address

Gent
STATE VETERINARY
Denmark
Address

Kalvehave
STATION DE PATHOLOGIE PORCINE
France
Address

Ploufragen