Objective
The project is to develop blood based laboratory tests for the diagnosis of bovine tuberculosis (BTB). This is necessary because the tuberculin test, which is the only officially approved test in the EC at present does not detect all cattle infected with Mycobacterium bovis and it is a time-consuming and expensive test. The immune response to Mycobacterium bovis is both cellular and humoral and the development of assays which will detect both of these responses is proposed. Antigens which are specific to Mycobacterium bovis will be identified and produced. This will be achieved by the use of extraction and purification from crude preparations, monoclonal antibody production, production of a cell wall antigen, production of fusion proteins containing multiple Mycobacterium bovis specific epitopes and the purification of glycolipid antigens. The cellular response to Mycobacterium bovis antigens will be detected in a bovine interleukin 2 assay. Methods to prolong the useful life of blood samples for cellular assays will be developed. The humoral response to Mycobacterium bovis antigens will be measured by ELISA using the specific antigens developed during the programme. The anamnestic effect of the injection of tuberculin on antibody production will also be investigated in infected cattle.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine pneumology tuberculosis
- agricultural sciences animal and dairy science domestic animals animal husbandry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DUBLIN 4
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.