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Résultats exploitables
In order to build a better understanding of lipid metabolism and to develop methods of enhancing the production of desirable compounds, the following activities were undertaken:
an investigation of metabolic switching between polyketide and fatty acid synthase in Aspergillus nidulans;
a study of the metabolic flux to cytosolic acetyl CoA in order to clone the gene encoding adenosine triphosphate (ATP): citrate lyase and thus to manipulate the levels of cytosolic acetyl CoA in A. nidulans;
fatty acid desaturation and chain length modification in the yeast Saccharomyces cerevisiae;
manipulation of genetically fatty acid biosynthesis in Apiotrichum curvatum (synonym Cryptococcus curvatus);
a study of the regulatory role of acyl CoA: diacylglycerol acyl transferase (DAGAT) in yeasts and moulds (this enzyme is necessary for the synthesis of triacylglycerol and is the only unique step because the immediate precursor is also used in the synthesis of phospholipids).
Metabolic switching and pathway manipulation in yeasts, filamentous fungi and plants were studied with a focus on the production of fatty acids and polyketides. Target species were chosen because of their detailed genetic history (Saccharomyces cerevisiae, Aspergillus nidulans and Brassica napus), their ability to accumulate fats/oils (Apiotrichum curvatum and Brassica napus) and moulds which are important in food biotechnology (Aspergillus niger).
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