Objectif
- To describe better the molecular defects leading to familial Mediterranean fever (FMF).
Expected Outcome
- The molecular basis of FMF and other forms of arthritis should be understood better, thus providing an opportunity for improved early diagnosis, therapy and prevention.
- Identification of a sufficient number of FMF families and preparation of a detailed clinical description of a series of Turkish, Spanish and non-Askhenazi Jewish patients with FMF serving as a basis for an optimal genetic mapping of the molecular defects in FMF;
- Genetic and physical mapping of the candidate regions of the FMF gene, first through the exclusion of gene-regions that have a recombinant event in an affected individual, and second, by a continuous mapping of identified candidate regions. The location of the disease gene will then be identified by molecular genetic techniques and through studying linkage disequilibria in each of the ethnic groups.
Thème(s)
Data not availableAppel à propositions
Data not availableRégime de financement
CSC - Cost-sharing contractsCoordinateur
07001 Palma de Mallorca
Espagne