CRITERIA FOR THE CHOICE AND DEFINITION OF HEALTHY VOLUNTEERS AND/OR PATIENTS FOR PHASE I AND II STUDIES IN DRUG DEVELOPMENT

Informations projet

N° de convention de subvention: B1

Projet clôturé

Date de début 24 Février 1986

Date de fin 23 Février 1991

Financé au titre de

• European cooperation in the field of scientific and technical research (COST), 1971-

Coût total

€ 25 000 000,00

Contribution de l’UE

Aucune donnée

Coordonné par

CEC
Belgium

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Publications

Other (33)

Recent dose-effect studies regarding antidepressants

Auteurs: PRESKORN S H (Deparment of Psychiatry and Behavioral Sciences, University of Kansas School of Medicine, Wichita and Psychiatric Research Institute (US))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 43-61, 1997, Page(s) 43-61, ISBN 92-828-3555-3

In search of the right comparator dose in antipsychotic drug evaluation studies: The case of Haloperidol

Auteurs: VAN KAMMEN D P (VA Pittsburgh Healthcare System and Department of Psychiatry, University of Pittsburgh (US))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 79-86, 1997, Page(s) 79-86, ISBN 92-828-3555-3

Is there a right dose of psychotropic drugs? A discussion of the methodological problems in clinical dose - effect studies

Auteurs: GRAM L F (Department of Clinical Pharmacology, Odense University (DK))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 1-11, 1997, Page(s) 1-11, ISBN 92-828-3555-3

Conference on the population approach: Measuring and managing variability in response, concentration and dose

Auteurs: CEC (CEC Bruxelles (BE))
Publié dans: Preliminary programme : EN (1996) 23pp. (euroabstract 34/1743), 1996, Page(s) 23, ISBN 92-827-7764-2

Influence of placebo in dose-response relationship studies

Auteurs: BERTSCHY G (Department of Psychiatry, University of Geneva (CH))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 87-98, 1997, Page(s) 87-98, ISBN 92-828-3555-3

D(2) occupancy and the mechanism of action of atypical antipsychotics: What's dose got to do with it?

Auteurs: PICKAR D ET AL (Experimental Therapeutics Branch, NIMH, Bethesda (US)), COPPOLA R ET AL (Clinical Brain Disorders Branch, NIMH, Bethesda (US))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 63-78, 1997, Page(s) 63-78, ISBN 92-828-3555-3

Neuro-imaging in antipsychotic drug dose-effect investigations

Auteurs: NYBERG S (Department of Clinical Neuroscience, Karolinska Hospital, Stockholm (SE))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 167-179, 1997, Page(s) 167-179, ISBN 92-828-3555-3

COST B1: Criteria for the choice and definition of healthy volunteers and/or patients in phase I and phase II studies in drug development

Auteurs: BOOBIS A R (EDITOR) (Imperial College School of Medicine, Department of Clinical Pharmacology, London (GB))
Publié dans: EUR 18394 EN (1998) 75pp., ECU 10.00, 1998, Page(s) 75, ISBN 92-827-4033-1

CYP1A2 activity and smoking influence the risk/benefit ratio of olanzapine in schizophrenic patients

Auteurs: CARRILLO J A, RAMOS S I, HERRÁIZ M A G, LOZANO L, BENÍTEZ J (Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz (ES))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 293-295, 1997, Page(s) 293-295, ISBN 92-828-3555-3

Pronounced differences in the plasma concentrations of clomipramine between Japanese and Swedish patients

Auteurs: SHIMODA K (Department of Medical Laboratory Sciences and Technology, Karolinska Institute at Huddinge University Hospital (SE)), YASUDA S (Department of Medical Laboratory Sciences and Technology, Karolinska Institute at Huddinge University Hospital (SE)), MORITA S (Department of Medical Laboratory Sciences and Technology, Karolinska Institute at Huddinge University Hospital (SE)), JERLING M (Department of Psychiatry, Shiga University of Medical Science (JP)), BÖTTIGER Y (Department of Psychiatry, Shiga University of Medical Science (JP)), BERTILSSON L (Department of Psychiatry, Shiga University of Medical Science (JP))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 251-255, 1997, Page(s) 251-255, ISBN 92-828-3555-3

The use of radioligands in human psychopharmacology: Focus on anxiety and benzodiazepine-GABA(A) receptors

Auteurs: MALIZIA A L (MRC Cyclotron Unit, Hammersmith Hospital, London (GB)), NUTT D J (MRC Cyclotron Unit, Hammersmith Hospital, London (GB))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 181-196, 1997, Page(s) 181-196, ISBN 92-828-3555-3

Clinical dose prediction of psychotropic drugs based on phase I studies

Auteurs: ROSENZWEIG P (Clinical Development Department, Synthélabo Recherche, Bagneux (FR))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 21-29, 1997, Page(s) 21-29, ISBN 92-828-3555-3

The relevance of time-dependent sensitisation (TDS) to the mechanism of action of antidepressant medications

Auteurs: SOARES J C (Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine (US)), ANTELMAN S M (Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine (US)), GERSHON S (Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine (US))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 105-114, 1997, Page(s) 105-114, ISBN 92-828-3555-3

Role of the acetylation polymorphism on clonazepam metabolism: Kinetic differences of transiently expressed human enzymes NAT2*4, NAT2*5B and NAT2*6A

Auteurs: OLIVERA M ET AL (Department of Pharmacology, University of Extremadura, Badajoz (ES))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 267-272, 1997, Page(s) 267-272, ISBN 92-828-3555-3

Use of dose/concentration - response data in psychotropic drug development

Auteurs: SITSEN A (NV Organon, Oss (NL))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 115-125, 1997, Page(s) 115-125, ISBN 92-828-3555-3

Determination of appropriate dosage in clinical development: Guidance

Auteurs: GOLDSTEIN D J (Neuroscience Division, Lilly Research Laboratories, Indianapolis (US)), POTTER W Z (Neuroscience Division, Lilly Research Laboratories, Indianapolis (US))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 305-322, 1997, Page(s) 305-322, ISBN 92-828-3555-3

CYP2D6 polymorphism among patients treated with thioridazine

Auteurs: LLERENA A (Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz (ES)), BERECZ R (Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz (ES)), BENÍTEZ J (Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz (ES)), DE LA RUBIA A (Psychiatric Hospital, Mérida (ES))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 285-289, 1997, Page(s) 285-289, ISBN 92-828-3555-3

Therapeutic drug monitoring of the SSRIs citalopram, paroxetine and sertraline in the treatment of depression in the elderly reduces drug costs

Auteurs: LUNDMARK J (Department of Psychiatry, Linköping University Hospital (SE)), NORDIN C (Department of Psychiatry, Linköping University Hospital (SE)), WÅLINDER J (Department of Psychiatry, Linköping University Hospital (SE)), BENGTSSON F (Clinical Pharmacology, Lund University Hospital (SE)), REIS M (Clinical Pharmacology, Lund University Hospital (SE))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 133-142, 1997, Page(s) 133-142, ISBN 92-828-3555-3

Role of CYP-enzymes in clinical psychopharmacology

Auteurs: AGÚNDEZ J A G (Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz (ES)), BENÍTEZ J (Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz (ES))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 257-266, 1997, Page(s) 257-266, ISBN 92-828-3555-3

Interaction between fluoxetine and clozapine: Pharmacokinetic and clinical implications

Auteurs: SPINA E ET AL (Institute of Pharmacology, University of Messina (IT)), FABRAZZO M ET AL (Department of Psychiatry, University of Naples (IT)), PERUCCA E (Department of Internal Medicine and Therapeutics, University of Pavia (IT))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 143-147, 1997, Page(s) 143-147, ISBN 92-828-3555-3

Antidepressants in the elderly: Assessment of serum anticholinergicity

Auteurs: POLLOCK B G (Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic (US)), NEBES R (Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic (US)), MULSANT B H (Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic (US))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 161-166, 1997, Page(s) 161-166, ISBN 92-828-3555-3

Receptor polymorphisms and psychotropic drug response

Auteurs: BROCKMÖLLER J (Institute of Clinical Pharmacology, University Clinic Charite, Humboldt University of Berlin (DE)), KAISER R (Institute of Clinical Pharmacology, University Clinic Charite, Humboldt University of Berlin (DE)), ROOTS I (Institute of Clinical Pharmacology, University Clinic Charite, Humboldt University of Berlin (DE))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 203-232, 1997, Page(s) 203-232, ISBN 92-828-3555-3

CYP2D6 polymorphism in psychiatric patients during haloperidol monotherapy

Auteurs: BERECZ R (Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz (ES)), LLERENA A (Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz (ES)), BENÍTEZ J (Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz (ES)), DE LA RUBIA A (Psychiatric Hospital, Mérida (ES))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 279-283, 1997, Page(s) 279-283, ISBN 92-828-3555-3

From theory to practice - is it easy? A study with hypnotic drugs

Auteurs: RAYÓN P, MONTERO D, MADURGA M, DE ABAJO F J (Area de Farmacovigilancia, Instituto de Salud Carlos III, Madrid (ES))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 197-201, 1997, Page(s) 197-201, ISBN 92-828-3555-3

Inhibition by some neurotransmitters of CYP3A activity in human liver microsomes

Auteurs: GERVASINI G ET AL (Department of Pharmacology, University of Extremadura, Badajoz (ES))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 273-278, 1997, Page(s) 273-278, ISBN 92-828-3555-3

European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs

Auteurs: BALANT L P (University of Geneva, Department of Psychiatry, Clinical Research Unit (CH)), BENÍTEZ J (University of Extremadura, Medical School, Department of Pharmacology and Psychiatry, Badajoz (ES)), DAHL S G (University of Tromsø, Department of Pharmacology (NO)), GRAM L F (Odense University, Department of Clinical Pharmacology (DK)), PINDER R M (NV Organon, Oss (NL)), POTTER W Z (EDITORS) (Lilly Research Laboratories, Indianapolis (US))
Publié dans: EUR 18168 EN (1997) 440pp., ECU 53, 1997, Page(s) 440, ISBN 92-828-3555-3

Inter-ethnic variability in psychotropic drug response

Auteurs: BALANT L P (Department of Psychiatry, University of Geneva (CH)), BALANT-GORGIA E A (Department of Psychiatry, University of Geneva (CH))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 233-249, 1997, Page(s) 233-249, ISBN 92-828-3555-3

Pharmacotherapy for the behavioural disorders of dementia: Application of pharmacogenetic probes

Auteurs: POLLOCK B G (Department of Psychiatry, University of Pittsburg School of Medicine (US))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 297-303, 1997, Page(s) 297-303, ISBN 92-828-3555-3

Role of active metabolites in the assessment of psychotropic drug response

Auteurs: BALANT L P (Department of Psychiatry, University of Geneva (CH)), GEX-FABRY M (Department of Psychiatry, University of Geneva (CH)), BALANT-GORGIA E A (Department of Psychiatry, University of Geneva (CH))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 127-132, 1997, Page(s) 127-132, ISBN 92-828-3555-3

Onset of response: A key issue in dose - concentration - effect studies

Auteurs: BALANT-GORGIA E A ET AL (Department of Psychiatry, Geneva University Hospitals (CH))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 99-104, 1997, Page(s) 99-104, ISBN 92-828-3555-3

Use of surrogate markers in clinical psychopharmacology

Auteurs: COWEN P J (University Department of Psychiatry, Warneford Hospital, Oxford (GB))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 151-160, 1997, Page(s) 151-160, ISBN 92-828-3555-3

On demonstrating the correct dose for new antidepressants: Dual action drugs

Auteurs: PINDER R M (NV Organon, Oss (NL)), ZIVKOV M (NV Organon, Oss (NL))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 31-42, 1997, Page(s) 31-42, ISBN 92-828-3555-3

Clinical dose prediction on the basis of preclinical data

Auteurs: BRILEY M (Institut de Recherche Pierre Fabre, Castres (FR))
Publié dans: Extract: European cooperation in the field of scientific and technical research: Clinical pharmacology in psychiatry: Finding the right dose of psychotropic drugs, Badajoz, Spain, 23-25 October 1997: Proceedings (1997) pp. 13-19, 1997, Page(s) 13-19, ISBN 92-828-3555-3