Objective
THE LEARNING TECHNIQUES BASED SOFTWARE WILL ALLOW A MORE EFFICIENT AND USER FRIENDLY ANALYSIS OF DNA AND PROTEIN SEQUENCE DATA AND WILL FORM AN IMPORTANT TOOL IN PROTEIN ENGINEERING.
It is now established that software holds the key to the success or the failure of international sequencing projects. In this context, work is being carried out in order to create the tools to help biologists in the analysis of structure and functions of each gene or group of genes.
Research involves the conception and implementation in an intelligent workstation of a computing environment which handles biosequences: access to databases, access to sequence analysis and learning software, display of sequences and results, communications with other computers and laboratories.
The design of the architecture of the system, BIOSTATION, in flexible and evolutive modules is being developed. 3 versions were written for the 1-dimensional, 2-dimensional and 3-dimensional display of sequences and analysis results. Realization and test of a prototype was carried out on a personal computer (PC). Extensive use has been made of the database software ACNUC and a program, CLUSTAL, was written for aligning many sequences. Also, CLUSTAL, portability of the system in OS/2 and UNIX operating systems have been linked.
A working methodology in design and realization of software for the computing of genomic sequence and the study of protein folding have been achieved. The first industrial exploitation of this work will be the diffusion of a commercial version BIOSTATION by a European company, GENOMIC, in 1991. A multiple sequence aligment program, CLUSTAL, was designed for microcomputer use. CLUSTAL is capable of aligning up to 100 sequences of 1200 residues each. This software has been distributed to 150 locations worldwide.
APPLICATION OF ARTIFICIAL INTELLIGENCE TECHNIQUES FOR THE PREDICTION OF MACROMOLECULE FUNCTIONS.
DEVELOPMENT OF TOOLS ALLOWING THE DECODING OF INFORMATION IN BIOLOGICAL SEQUENCES. TWO APPROACHES ARE PROPOSED FOR DEVELOPMENT.:
-SOFTWARE FOR THE ANALYSIS OF SEQUENCES USING LEARNING TECHNIQUES.
-AN INTERFACE ALLOWING BIOLOGISTS TO USE THE RULES IN THE ABOVE SOFTWARE. THESE RULES ARE USED TO CONSTRUCT PEPTIDE OR DNA SEQUENCES WITH A GIVEN FUNCTION.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences artificial intelligence
- natural sciences computer and information sciences software software applications system software operating systems
- natural sciences computer and information sciences databases
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins protein folding
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Coordinator
34100 Montpellier
France
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