Objective
- BEST UNDERSTANDING OF THE ANTIGENIC POLYMORPHISM OF AFRICAN SWINE FEVER.
- EVENTUALLY, PRODUCTION OF A VACCINE AGAINST THIS DISEASE.
African swine fever (ASF) is an infectious disease of domestic pigs and acari of the genus Ornithodoros. In the pig, the major target cell is the macrophage and research has been carried out to see whether or not the porcine macrophage has a specific receptor for the virus and, if so, to identify the virus attachment protein, to map the gene, to sequence and express it in sufficient amounts to carry out protection experiments in pigs. Porcine macrophages, but not macrophages from animal species resistant to the virus, have been found to have a specific receptor for ASF virus. The attachment of the virus to the macrophage occurred through an external protein (p12) in the virion, and this interaction was necessary to induce infection. The gene coding for protein p12 has been mapped and sequenced and work is in progress to express the gene to obtain enough protein p12 to carry out protection experiments.
THE AIM OF THIS PROJECT IS TO ISOLATE A PROTEIN CAPABLE TO INDUCE A PROTECTIVE RESPONSE AGAINST ASF VIRUS. THE PROJECT CONSIST IN FOUR STEPS :
- IDENTIFICATION OF VIRAL PROTEINS EXPOSED IN VIRIONS AND VIRUS INFECTED CELLS.
- ISOLATION OF MONOCLONAL AND MONOSPECIFIC ANTIBODIES.
- GENE MAPPING.
- NEUTRALIZING AND PROTECTING ANTIBODIES.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MADRID 34
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.