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APPLICATION OF MICRODOSIMETRIC METHODS TO RADIATION PROTECTION AND INVESTIGATION OF MECHANISMS OF DNA STRAND-BREAK INDUCTION AND REPAIR

Objective

THIS PROPOSAL WILL PROVIDE MORE INFORMATION ON DOSIMETRY FOR THE PROTECTION OF WORKERS AND THE POPULATION. AREA MONOTORING AND DOSIMETRIC METHODS FOR INCORPORATED RADIONUCLIDES WILL BE IMPROVED.
Studies were directed at the implementation of a low pressure proportional counter for use as a diagnostic working area and environmental dosimeter of high sensitivity and high dynamic range in linear energy transfer (LET), and the determination of the magnitude and meaning of local dose profiles around single decays of incorporated radionuclides in radiation protection.
IN THE PAST 5 YEARS, IN THIS INSTITUTE, TECHNICAL AND COMPUTATIONAL MICRODOSIMETRIC INSTRUMENTATIONS AND METHODS HAVE BEEN DEVELOPED FOR DIRECT APPLICATION TO RADIATION PROTECTION. THE TWO PROJECTS DEAL WITH THE IMPLEMENTATION OF THESE INSTRUMENTS AND METHODS TO RADIATION PROTECTION.
A. IMPLEMENTATION OF A LOW-PRESSURE PROPORTIONAL COUNTER FOR USE AS A DIAGNOSTIC WORKING AREA AND ENVIRONMENTAL DOSIMETER OF HIGH SENSITIVITY AND HIGH DYNAMIC RANGE IN LET
IN 1981/1984 THE INSTITUTE OF MEDICINE AND THE CENTRAL INSTITUTE OF ELECTRONICS, KFA JUELICH, DEVELOPED A PORTABLE DOSE-EQUIVALENT METER. FOR 1985/1989 IT IS PROPOSED TO IMPLEMENT THE DEVELOPED INSTRUMENT FOR ITS USE AS WORKING AREA AND ENVIRONMENTAL DOSIMETER IN RADIATION PROTECTION PRACTICE. AS BEFORE, THIS WORK WILL BE PERFORMED IN CLOSE COLLABORATION WITH THE SCIENTISTS COOPERATING IN EURADOS COMMITTEE I.
THE IMPLEMENTATION WILL INVOLVE CALIBRATION MEASUREMENTS CHECKING THE PRECISION, INTERPRETATION AND PERFORMANCE OF THE SYSTEM.
B. MAGNITUDE AND MEANING OF LOCAL DOSE PROFILES AROUND SINGLE DECAYS OF INCORPORATED RADIONUCLIDES IN RADIATION PROTECTION.
IN 1981/1984 COMPUTER PROGRAMMES WERE DEVELOPED FOR THE CALCULATION OF LOCAL DOSE AROUND RADIONUCLIDES DISINTEGRATING IN CONDENSED TISSUE, INCLUDING THE PROBLEM OF CHARGE-POTENTIAL BUILT-UP DUE TO AUGER-ELECTRON CASCADES. IT IS PROPOSED TO USE THIS CODE TO CALCULATE THE LOCAL DOSE IN THE AVERAGE HUMAN CELL NUCLEUS AS A BASIS FOR POSSIBLE NEW CONCEPTS FOR THE EVALUATION OF RADIATION PROTECTION LIMITS FOR ARBITRARY INCORPORATED RADIONUCLIDES.
AS A FIRST STEP, LOCAL PROFILES FOR RADIONUCLIDES OF INTEREST IN RADIATION PROTECTION AND THEIR LOCAL ENERGY DEPOSITION INTO CRITICAL TARGETS WILL BE CALCULATED IN COLLABORATION WITH GOODHEAD AND CHARLTON (MRC, HARWELL), PARETZKE (GSF, HEUHERBERG) AND BLANC (CPA, TOULOUSE).
AS THE SECOND STEP, INVESTIGATION OF THE ENERGY IMPARTED TO THE AVERAGE HUMAN CELL NUCLEUS AS A BASIS FOR POSSIBLE NEW CONCEPTS FOR THE EVALUATION OF RADIATION PROTECTION LIMITS.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

FORSCHUNGSZENTRUM JUELICH GMBH
Address
Wilhelm Johnen Strasse
52425 Juelich
Germany