Objective
Studies have been conducted on radiation induced effects on thyroid cell survival and function, and of the dosimetry of radioiodine in cell cultures, as well as on the carcinogenic aspects of thyroid irradiation.
The project has demonstrated that the proliferative radiobiology of the thyroid can be understood within the same framework as the applied to other tissues. Survival, recovery and fractionation respose in different cell cultures are within the range observed for many mammalian cell systems. The dose for sheep cells is the order of 2 Gy and that for cells of human origin is in the range of 0.5-2.0 Gy. The rbe for 131-I is 0.16-0.2 and the response to it may be explained on the basis of dose rate. Furthermore, the thyroid response has been characterised within the framework of a unified model that integrates cell survival data obtained in cultures; older cell survival data using the gland weight assay; the incidence of post irradiadion hypothyroidism and a postulated cell kinetics structure for the gland. In summary, the project reported on have added notably to knowledge of thyroid radiation responses and dosimetry during the last four years.
The work has demonstrated that the proliferative radiobiology of the thyroid can be understood within the same framework as that applied to other tissues. Survival, recovery and fractionation response in different cell cultures are within the range observed for many mammalian cell systems. The dose for sheep cells is of the order of 2 Gy and that for cells of human origin is in the range of 0.5-2.0 Gy.
The relative biological effectiveness (RBE) for iodine-131 is 0.16-0.2 and the response to it may be explained on the basis of dose rate. Furthermore, the thyroid response has been characterised within the framework of a unified model that integrates cell survival data obtained in cultures, older cell survival data using the gland weight assay, the incidence of post irradiadion hypothyroidism and a postulated cell kinetics structure for the gland.
1. STUDIES OF RADIATION INDUCED EFFECTS ON THYROID CELL SURVIVAL AND FUNCTION, AND OF THE DOSIMETRY OF RADIOIODINE IN CELL CULTURES.
2. CARCINOGENIC ASPECTS OF THYROID IRRADIATION.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DUBLIN 8
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.