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RADIATION RESPONSE OF THE THYROID: SURVIVAL AND ALTERATION TOWARDS MALIGNANCY IN CELL CULTURE AND HUMAN SYSTEMS

Objective


Studies have been conducted on radiation induced effects on thyroid cell survival and function, and of the dosimetry of radioiodine in cell cultures, as well as on the carcinogenic aspects of thyroid irradiation.

The project has demonstrated that the proliferative radiobiology of the thyroid can be understood within the same framework as the applied to other tissues. Survival, recovery and fractionation respose in different cell cultures are within the range observed for many mammalian cell systems. The dose for sheep cells is the order of 2 Gy and that for cells of human origin is in the range of 0.5-2.0 Gy. The rbe for 131-I is 0.16-0.2 and the response to it may be explained on the basis of dose rate. Furthermore, the thyroid response has been characterised within the framework of a unified model that integrates cell survival data obtained in cultures; older cell survival data using the gland weight assay; the incidence of post irradiadion hypothyroidism and a postulated cell kinetics structure for the gland. In summary, the project reported on have added notably to knowledge of thyroid radiation responses and dosimetry during the last four years.

The work has demonstrated that the proliferative radiobiology of the thyroid can be understood within the same framework as that applied to other tissues. Survival, recovery and fractionation response in different cell cultures are within the range observed for many mammalian cell systems. The dose for sheep cells is of the order of 2 Gy and that for cells of human origin is in the range of 0.5-2.0 Gy.
The relative biological effectiveness (RBE) for iodine-131 is 0.16-0.2 and the response to it may be explained on the basis of dose rate. Furthermore, the thyroid response has been characterised within the framework of a unified model that integrates cell survival data obtained in cultures, older cell survival data using the gland weight assay, the incidence of post irradiadion hypothyroidism and a postulated cell kinetics structure for the gland.
1. STUDIES OF RADIATION INDUCED EFFECTS ON THYROID CELL SURVIVAL AND FUNCTION, AND OF THE DOSIMETRY OF RADIOIODINE IN CELL CULTURES.
2. CARCINOGENIC ASPECTS OF THYROID IRRADIATION.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

FEDERATED DUBLIN VOLUNTARY HOSPITALS
Address
Po Box 795
Dublin 8
Ireland