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METABOLISME ET EFFETS DES ACTINIDES

Objective


In plutonium oxide exposed rats a significant impairment of natural killer (NK) defences was observed since the lungs had 2 to 5 times more viable tumour cells than control lungs. Moreover, the drop in NK cell activity increased with time from 9 to 90 days after inhalation. However, plutonium oxide exposed animals treated by Poly IC regrew a number of tumour cells roughly similar to the number of tumour cells present in nonstimulated controls.
This result shows that it is possible to obtain a restoration of NK activity in animals exposed to plutonium oxide. However, further experiments are needed to test the effect of this NK restoration on the incidence of plutonium oxide induced lung tumours.
1. STUDY OF THE BIOLOGY OF PU-TRILAURYLAMINE COMPLEX, COMPARISON WITH PU-TRIBUTYL PHOSPHATE.
2. STUDY OF TRANSURANICS GUT TRANSFER AND MECHANISM; EFFECTS OF VALENCY STATE, AGE AND REGIMEN.
3. STUDY OF THE ROLE OF INTRACAPILLARY LYMPHOCYTES ON THE GROWTH OF PU02-INDUCED LUNG TUMOURS.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

COMMISSARIAT A L'ENERGIE ATOMIQUE
Address
Rue De La Federation 31-33
75015 Paris
France