Objective
In plutonium oxide exposed rats a significant impairment of natural killer (NK) defences was observed since the lungs had 2 to 5 times more viable tumour cells than control lungs. Moreover, the drop in NK cell activity increased with time from 9 to 90 days after inhalation. However, plutonium oxide exposed animals treated by Poly IC regrew a number of tumour cells roughly similar to the number of tumour cells present in nonstimulated controls.
This result shows that it is possible to obtain a restoration of NK activity in animals exposed to plutonium oxide. However, further experiments are needed to test the effect of this NK restoration on the incidence of plutonium oxide induced lung tumours.
1. STUDY OF THE BIOLOGY OF PU-TRILAURYLAMINE COMPLEX, COMPARISON WITH PU-TRIBUTYL PHOSPHATE.
2. STUDY OF TRANSURANICS GUT TRANSFER AND MECHANISM; EFFECTS OF VALENCY STATE, AGE AND REGIMEN.
3. STUDY OF THE ROLE OF INTRACAPILLARY LYMPHOCYTES ON THE GROWTH OF PU02-INDUCED LUNG TUMOURS.
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75015 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.