Objective
THERE IS INCREASING EVIDENCE THAT THE ACTIVITIES OF GENETICALLY-DETERMINED DNA REPAIR FUNCTIONS ARE MAJOR FACTORS INFLUENCING THE RESPONSE OF MAMMALIAN CELLS TO IONIZING RADIATION. MUTATION AND RECOMBINATION ARE IMPORTANT RESPONSES TO RADIATION DAMAGE: THEY MAY LEAD TO GENETIC DISORDERS IN MAN AS WELL AS PREDISPOSITION TO A VARIETY OF HARMFUL AGENTS. DURING THE LAST FEW YEARS THERE HAVE BEEN REMARKABLE ADVANCES IN RECOMBINANT DNA TECHNIQUES WHICH MAY BE APPLIED TO THE STUDY OF REPAIR PROCESSES AND THE ANALYSIS OF MUTATION AND RECOMBINATION. IN THE PROPOSALS GIVEN BELOW GENE TRANSFER AND RECOMBINANT DNA TECHNIQUES WILL BE USED TO STUDY MOLECULAR ASPECTS OF RADIATION RESPONSE IN CULTURED MAMMALIAN CELLS.
Studies being carried out concern:
the molecular basis of mutation and recombination in mammalian cells differing in capacity to repair radiation damage;
the isolation and cellular and molecular characterisation of repair deficient mammalian cell lines;
the cloning and analysis of radiation repair genes from lower organisms and their introduction into mammalian cells.
1 - THE MOLECULAR BASIS OF MUTATION AND RECOMBINATION IN MAMMALIAN CELLS DIFFERING IN CAPACITY TO REPAIR RADIATION DAMAGE.
2 - THE ISOLATION AND CALLULAR AND MOLECULAR CHARACTERISATION OF REPAIR-DEFICIENT MAMMALIAN CELL LINES.
3 - THE CLONING AND ANALYSIS OF RADIATION REPAIR GENES FROM LOWER ORGANISMS AND THEIR INTRODUCTION INTO MAMMALIAN CELLS.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences genetics DNA
- natural sciences physical sciences nuclear physics
- natural sciences biological sciences genetics mutation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
W1N 4AL London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.