Objective
THE PROJECT WILL PURSUE THE BIOCHEMICAL ANALYSIS OF DNA REPAIR IN HUMAN AND MAMMALIAN CELLS, WITHIN A JOINT PROGRAMME . OUR CONTRIBUTION TO THIS COLLABORATION WILL BE FOCUSED ON THE INVESTIGATION INTO THE PRIMARY EFFECTS OF RADIATION, VIZ., THE REACTION PRODUCTS FORMED WITH THE INTRACELLULAR TARGET, THE DNA IN THE CHROMOSOMES. WE AIM AT THE DETECTION, IDENTIFICATION AND QUANTITATIVE DETERMINATION OF THESE PRODUCTS.
Radiation induced lesions were detected using 2 approaches. Firstly, immunochemical methods were used, which included the production of antibodies against radiation induced lesions and the development of immunochemical assays based on the antisera were obtained. Secondly, biochemical methods were used, which included the development of an alkaline elution method for the sensitive detection of single strand breaks, using fluorometric quantisation of deoxyribonucleic acid (DNA).
The methods developed were then used in studies of the induction and repair of DNA lesions in cells exposed to ionising radiation of UV, either in vitro or in vivo.
Immunochemical and biochemical methods have been developed and applied in studies on the induction and repair of deoxyribonecleic acid (DNA) lesions in cells exposed to ionising radiation or ultraviolet (UV) radiation either in vitro or in vivo.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics chromosomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2595 CL DEN HAAG
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.