Objective The aim of the project was to examine the distribution, type and consequences of spontaneous and radiation induced deletions in the human chromosome complement with emphasis on the short arm of chromosome 11. Chromosome 11 was selected since it was known to contain a number of genes involved in carcinogenesis (eg Wilms' tumour, H-ras 1,T cell acute leukaemia) and to sustain a larger number of deletions than expected on chromosome length following exposure to ionising radiation. Constitutional deletions of the short arm of chromosome 11 were consistent with viability when hetrozygous and various sizes of deletions were available in the human population which were associated with specific disease states (eg Wilms' tumour, aniridia etc).SPONTANEOUS AND RADIATION-INDUCED CHROMOSOME MUTATION AND DELETIONS OF SPECIFIC CHROMOSOME REGIONS OF THE HUMAN KARYOTYPE WHICH CONTAIN GENES OF KNOWN CLINICAL IMPORTANCE. Fields of science natural sciencesbiological sciencesgeneticsmutationmedical and health sciencesclinical medicineoncologyleukemianatural sciencesbiological sciencesgeneticschromosomes Programme(s) FP1-RADPROT 6C - Multiannual research and training programme (Euratom) in the field of radiation protection, 1985-1989 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator Medical Research Council (MRC) Address 20 park crescent W1N 4AL London United Kingdom See on map EU contribution € 0,00
