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SPONTANEOUS AND RADIATION-INDUCED CHROMOSOME MUTATION AND DELETIONS OF SPECIFIC CHROMOSOME REGIONS OF THE HUMAN KARYOTYPE WHICH CONTAIN GENES OF KNOWN CLINICAL IMPORTANCE

Objective


The aim of the project was to examine the distribution, type and consequences of spontaneous and radiation induced deletions in the human chromosome complement with emphasis on the short arm of chromosome 11. Chromosome 11 was selected since it was known to contain a number of genes involved in carcinogenesis (eg Wilms' tumour, H-ras 1,T cell acute leukaemia) and to sustain a larger number of deletions than expected on chromosome length following exposure to ionising radiation. Constitutional deletions of the short arm of chromosome 11 were consistent with viability when hetrozygous and various sizes of deletions were available in the human population which were associated with specific disease states (eg Wilms' tumour, aniridia etc).
SPONTANEOUS AND RADIATION-INDUCED CHROMOSOME MUTATION AND DELETIONS OF SPECIFIC CHROMOSOME REGIONS OF THE HUMAN KARYOTYPE WHICH CONTAIN GENES OF KNOWN CLINICAL IMPORTANCE.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Medical Research Council (MRC)
Address
20 Park Crescent
W1N 4AL London
United Kingdom