Objectif The aim of the project was to examine the distribution, type and consequences of spontaneous and radiation induced deletions in the human chromosome complement with emphasis on the short arm of chromosome 11. Chromosome 11 was selected since it was known to contain a number of genes involved in carcinogenesis (eg Wilms' tumour, H-ras 1,T cell acute leukaemia) and to sustain a larger number of deletions than expected on chromosome length following exposure to ionising radiation. Constitutional deletions of the short arm of chromosome 11 were consistent with viability when hetrozygous and various sizes of deletions were available in the human population which were associated with specific disease states (eg Wilms' tumour, aniridia etc).SPONTANEOUS AND RADIATION-INDUCED CHROMOSOME MUTATION AND DELETIONS OF SPECIFIC CHROMOSOME REGIONS OF THE HUMAN KARYOTYPE WHICH CONTAIN GENES OF KNOWN CLINICAL IMPORTANCE. Champ scientifique sciences naturellessciences biologiquesgénétiquemutationsciences médicales et de la santémédecine cliniqueoncologieleucémiesciences naturellessciences biologiquesgénétiquechromosome Programme(s) FP1-RADPROT 6C - Multiannual research and training programme (Euratom) in the field of radiation protection, 1985-1989 Thème(s) Data not available Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur Medical Research Council (MRC) Adresse 20 park crescent W1N 4AL London Royaume-Uni Voir sur la carte Contribution de l’UE Aucune donnée
