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ROLE OF RECOMBINATION IN YEAST MITOCHONDRIAL DNA REPAIR. INFLUENCE OF IONIZING RADIATION

Objective

RESEARCH AIMS TO UNDERSTAND AT THE MOLECULAR LEVEL THE MECHANISMS OF THE RECOMBINATION OF MT DNA AND ITS ROLE IN REPAIR PROCESSES.
It has been shown that the mitochondrial deoxyribonuleic acid (DNA) of Saccharomyces cerevisiae is subject to efficient repair after ultraviolet (UV) light, ethidium bromide or ionising radiation treatments, mainly through a recombinational pathway. An essential member of this repair pathway has been characterised. The PIF1 gene which is required for the efficient recognition of a recombinogenic signal encodes a mitochondrial DNA helicase which is related to a family of multifunctional DNA helicases of Escherichia coli. The gene MIP1 that encodes the mitochondrial DNA polymerase has also been characterised. This enzyme must also play an important role in repair functions and it has been shown that it contributes to the accuracy of the transmissions of the mitochondrial genetic information through the generations.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITE CATHOLIQUE DE LOUVAIN
Address
Place De L'universite 1
Louvain-la-neuve
Belgium