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STUDY OF THE EFFECTS OF RADIATION ON THE CHROMOSOMES OF HUMAN GAMETES

Objective


The object of this research was to refine further the techniques of human sperm chromosome analysis, based on the in vitro fertilisation of zona free hamster eggs, by the use of electropermeabilisation for the induction of a functional acrosome reaction in the spermatozoa and the use of a totally defined medium for gamete culture. This adapted technique was applied to an investigation of the effect of radiation on the induction of cytogenetic aberration.
RESEARCH INTENDS TO STUDY DIRECTLY THE EFFECTS OF RADIATION ON THE INDUCTION OF CHROMOSOME ABNORMALITIES IN HUMAN SPERM TAKING INTO ACCOUNT PARAMETERS SUCH AS AGE, DISEASE, ENVIRONMENTAL AND PHYSIOLOGICAL CONDITIONS.

EXPECTED BENEFITS

EVALUATION OF GENETIC RISKS FROM IONIZING RADIATION. DETERMINATION OF GENETIC DAMAGE IN MAN ON THE BASIS OF CHROMOSOME ABERRATIONS.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY COLLEGE GALWAY
Address
Irl- Galway

Ireland