Objective The object of this research was to refine further the techniques of human sperm chromosome analysis, based on the in vitro fertilisation of zona free hamster eggs, by the use of electropermeabilisation for the induction of a functional acrosome reaction in the spermatozoa and the use of a totally defined medium for gamete culture. This adapted technique was applied to an investigation of the effect of radiation on the induction of cytogenetic aberration.RESEARCH INTENDS TO STUDY DIRECTLY THE EFFECTS OF RADIATION ON THE INDUCTION OF CHROMOSOME ABNORMALITIES IN HUMAN SPERM TAKING INTO ACCOUNT PARAMETERS SUCH AS AGE, DISEASE, ENVIRONMENTAL AND PHYSIOLOGICAL CONDITIONS. EXPECTED BENEFITS EVALUATION OF GENETIC RISKS FROM IONIZING RADIATION. DETERMINATION OF GENETIC DAMAGE IN MAN ON THE BASIS OF CHROMOSOME ABERRATIONS. Fields of science natural sciencesphysical sciencesnuclear physicsnatural sciencesbiological sciencesgeneticschromosomes Programme(s) FP1-RADPROT 6C - Multiannual research and training programme (Euratom) in the field of radiation protection, 1985-1989 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY COLLEGE GALWAY Address Irl- galway Ireland See on map EU contribution € 0,00
