Objective
EVALUATION OF RISKS FROM RADIATION-INDUCED CANCER.
DETERMINATION OF THE ROLE OF DNA METHYLATION.
IT IS PROPOSED TO INVESTIGATE WHETHER AND HOW IN AN IN VITRO CELLULAR SYSTEM, CAPABLE OF CELL DIFFERENTIATION UNDER CONTROLLED CONDITIONS, EXPOSURE TO IONIZING RADIATION MODIFIES, IN A CORRELATED MANNER, THE DNA METHYLATION PATTERN AND THE CULTURAL AND/OR DIFFERENTIATION CHARACTERISTICS.
Research work includes:
studying the effects of sublethal exposure to X-irradiation on specific gene expression by cultured cells endowed with a deoxyribonucleic acid (DNA) methylation sensitive tendency to undergo terminal differentation;
studying the effects of DNA methylation inhibitors on the susceptibility to radiation damage of cultured mammalian cells;
evaluating single strand breaks occurring in nuclear DNA during cell differentiation and/or exposure to X-rays;
identifying factors which regulate, within chromatic structure and at the single gene level, the susceptibility to in vitro methylation of particular CpG sequences in DNA.
A STUDY OF THE LEVEL OF METHYLATION OF DNA IN THE REPAIR OF RADIATION INDUCED DAMAGE, ITS EFFECT ON DIFFERENTIATION, TRANSMISSION TO DAUGHTER CELLS AND ITS POTENTIAL ROLE IN CELL TRANSFORMATION.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences physical sciences nuclear physics
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ROMA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.