Objetivo
Atopic allergic diseases affect a constantly increasing segment of the population. At present, treatments are mostly confined to symptomatic drug regimens. Allergen-driven desensitization programs are used with moderate success. Any innovative form of immunotherapy for Type-I allergies should therefore be aimed at the interference with the underlying immunological mechanisms. The aim of the present research project is to develop a targeting technology to significantly improve immunotherapy using chemically modified allergens. For this, we will use our recent patented discovery that targeting of antigen to antigen presenting cells via Fc-receptor (FcR) bridging results in disabled presentation of the antigen and in antigen-specific inactivation of T cells. This should lead to a better and safer treament modality for Type-I allergies.
Ámbito científico
CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural.
CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural.
Convocatoria de propuestas
Data not availableRégimen de financiación
EAW - Exploratory awardsCoordinador
1105 BE Amsterdam
Países Bajos