Objective
The normal biological variation of the human brain is almost entirely unknown. No one has yet quantitatively and systematically assessed the variations in functional activation, and microstructure of the human brain. We propose development of a European Computerised Human Brain Database (ECHBD) for the purpose of storage, manipulation and quantitative evaluation of all quantitative neuroscience data of the human brain in a standard format and to serve as a microstructural-functional model of the human cerebral cortex. When further developed the ECHBD contains all information in a standard anatomical format, as a 3D set of pictures which each in its more than 6 million points contains quantitative data as well as their mean and variances of more than 30 types of measurements. The project features:
-- all individual brains mapped in the same format.
-- multi-resolution ranging from 1 mm3 voxels to llm3 voxels. -- advanced mathematical picture analysis, automatic 3D image transformations, 2D planar representations of the cortex and the development of a standard brain in 3D.
-- a mainly visually organized database in a standard 3D format and additional unfolded 2D representations of the cortex and cortical laminae. -- quantitative positron emission tomography of regional cerebral blood flow and regional cerebral metabolism, functional magnetic resonance tomography, magneto- encephalography, and EEG mapping.
-- quantitative cytoarchitectonic measurements, myeloarchitectonic measurements, receptor architectonic measurements, counts of neurons in strictly defined regions, neurochemical measurements, and measurements of expressions of mRNA.
-- the establishment of homologies between microstructural data in the human brain and microstructural data in the macaque brain. Studies of cortico-cortical connections in humans in selected cases.
-- interface in Java internet environment and support for different 3D-picture formats, securing communication and free distribution of software to European researchers.
The contents of the database provide multiple criteria for parceling the human cerebral cortex into functional and structurally defined local regions. The database is also a model of the human cerebral cortex and a tool for examining hypotheses and generating hypotheses about structural/functional relations in the human brain. This strategy has already proved to work. In addition, the ECHBD is a reference for all structural and functional mapping studies of the human brain, it enables studies of the variance in normal populations, enables modelling and hypotheses generation based on known connectivity in sub-human primates and the database constitutes the first ever beginning quantitative neurobiological description of the normal human brain.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological scienceszoologymammalogyprimatology
- natural sciencesbiological sciencesneurobiology
- natural sciencescomputer and information sciencessoftware
- natural sciencescomputer and information sciencesinternet
- natural sciencescomputer and information sciencesdatabases
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
171 77 STOCKHOLM
Sweden