Objective
Summary Extremophilic archaea and bacteria have tremendous potential in biotechnology because of their ability to grow under extreme conditions and to produce unique stable products with high technological value. A number of enzymes from hyperthermophiles like Pyrococcus and Thermococcus, that are involved in DNA processing, are already on the market. The objective of this integrated project is aiming at the production of industrial enzymes (e.g. hydrolases and DNA polymerases) and other products (organic solutes and lipids) from selected extremophiles. Research work will be concentrating on few model organisms including hyperthermophiles (Pyrococcus, Thermococcus, Pyrodictium), extreme thermophiles (Thermotoga, Rhodothermus, Sulfolobus), psychrophiles ( Vibrio) and halophiles (Marinococcus). In order to overcome the limited production of enzymes and other organic compounds and in order to tailor these for specific applications the proposed project will be performed in an interdisciplinary manner involving (a) genetic engineering, (b) fermentation technology and (c) product engineering.
Various strategies will be used with the aim of optimization of growth of selected extremophiles. A special pilot plant bioreactor will be constructed which will allow a high mass transfer capacity between liquid and gaseous phase. Specific attention will be given to the development of expression systems for hyperthermophiles, thermoacidophiles and halophiles. The overexpression of novel products in extreme thermophiles and mesophiles will allow for further exploitation of the potential of these microbes. The analysis of structure-function relationships, the clarification of stability and specificity and catalysis mechanism will be needed to use enzymes from extremophiles in diagnostics, molecular biology and other industrial processes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology mechanical engineering manufacturing engineering product engineering
- natural sciences chemical sciences organic chemistry
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- natural sciences biological sciences molecular biology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
21071 Hamburg
Germany
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Participants (39)
8636 Wald
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82377 Penzberg
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24118 KIEL
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29682 Roscoff
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3000 Coimbra
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2288 GJ RIJSWIJK ZH
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112 Reykjavik
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29280 PLOUZANE
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141 57 Huddinge
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1307 København K
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221 00 Lund
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82152 MARTINSRIED
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53332 Bornheim-Hersel
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SP4 0JG SALISBURY
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15700 Athens
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15701 Athens
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2880 Bagsværd
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1031 Wien
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20132 Milano
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112 REYKJAVIK
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8010 Graz
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41012 SEVILLA
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80134 NAPOLI
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91405 GOMETZ LA VILLE
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9751 NN HAREN GN
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LE1 9HN LEICESTER
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LUEBECK
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2780 Oeiras
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45117 Essen
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93053 Regensburg
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4 Dublin
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WC1E 6BT London
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0108 Reykjavik
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45110 Ioannina
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S10 2UH Sheffield
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80138 Napoli
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00185 Roma
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6703 CT WAGENINGEN
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48149 Münster
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