Objective
The present research project foresees the synthesis of peptides and, in the following, of peptidomimetics corresponding to a discrete, non-polymorphic, domain of major histocompatibility complex (MHC) class II molecules. On the basis of theoretical considerations and preliminary results such compounds should be able to interfere with the antigen-specific activation of CD'-positive T cells through a novel mechanism of action. Thus, such peptides should not act through occupation of the antigen-binding groove of MHC class II molecules. Preliminary results have shown that linear up to 16 amino acid long peptides corresponding to said domain are indeed able to inhibit the antigen-specific activation of CD4-positive T cells but not of CD8-positive T cells. The concentration of such peptides yielding half-maximal inhibition was 30-100 uM. This inhibition could be shown not being due to occupation of the antigen-binding groove of MHC class II molecules and indirect experimental evidence suggests that they do so by binding to MHC class II molecules. The work programme foresees the synthesis of other peptides that will be shorter than the parent compounds and of constrained chemical structure. Such peptides will be tested in several assays for antigen-specific T cell activation. Further peptides will be synthesized having properties that should make them suitable for in vivo administration. Such peptides will be tested in several in vivo models of T cell activation. Optimally, on the basis of the acquired knowledge, it is then foreseen to synthesise peptidoimetics that may be suitable pharmacological agents for diseases states that are the consequence of activation and expansion of CD4-positive T cells.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- natural sciences chemical sciences organic chemistry amines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75008 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.