Prevention of the appearance of resistance to beta-lactam antibiotics in streptococcus pneumoniae: exploring strategies based on microbial ecology

Project Information

Grant agreement ID: BIO4980424

Project closed

Start date 1 October 1998

End date 30 September 2000

Funded under

• Specific research, technological development and demonstration programme in the field of biotechnology, 1994-1998

Total cost No data

EU contribution No data

Coordinated by

INSTITUTO NACIONAL DE LA SALUD
Spain

Objective

The classical ways to fight against bacterial pathogens start to be exhausted. During the last 20 years, not a single new family of antibiotics has arrived to the common clinical practice.
At the same time, the huge consumption of antibiotics (more than 1 ton/day in some european countries) is creating a deep alteration in normal microbial ecology, with a worldwide selection and spread of antibiotic resistant clones that require of innovative strategies to be controlled. Indeed pharmaceutical industry has created an environmental health problem. Vaccination against many respiratory pathogens may also have undesirable ecological consequences, Accordingly with the proposals of the new <>, measures to counteract environmental damage should be investigated and urgently applied. This Project was designed to explore some biotechnological possibilities based on microbial ecology, and focus one of the most relevant problems of current antibiotic therapy: infections caused by the ubiquitous Streptococcus pneumoniae. The microbial ecology of streptococcal populations remains poorly understood. It is critical to understand better the ecological-environmental factors regulating clonal selection, colonization, bacterial interference, and horizontal gene transfer. The study of these factors is the main goal of this Project, developing a collection of minimis ed Streptococcus genomes and exploring the fate of them in the animal model by the use of a marker (green fluorescent protein), and searching for colonization and horizontal gene transfer. New targets for non-antibiotic compounds interfering the acquisition of resistance, or biotherapeutic and bio-restaurative non-pathogenic strains may be found as a result of this Project.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• medical and health sciences › health sciences › public health
• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• natural sciences › biological sciences › ecology
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › antibiotics
• medical and health sciences › basic medicine › pharmacology and pharmacy › drug resistance › antibiotic resistance

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Programme(s)

• FP4-BIOTECH 2 - Specific research, technological development and demonstration programme in the field of biotechnology, 1994-1998

Topic(s)

• 070201 - Microbial ecology

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUTO NACIONAL DE LA SALUD

• EU contribution: No data
• Address: KM 9.1,Crta.de Colmenar KM 9.1 ; 28034 MADRID ; Spain
• Total cost: No data

Participants (4)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

• EU contribution: No data
• Address: Route de Narbonne 118 Univ. P.Sabatier Toulouse 3 ; 31062 Toulouse
• Total cost: No data

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

• EU contribution: No data
• Address: Calle Serrano 117 ; MADRID
• Total cost: No data

Glaxo Wellcome SpA

Italy

• EU contribution: No data
• Address: Via A. Fleming 2 ; 37100 Verona
• Total cost: No data

UNIVERSITAET KAISERSLAUTERN

Germany

• EU contribution: No data
• Address: Paul-Ehrlich-Strasse 23 ; 67663 KAISERSLAUTERN
• Total cost: No data