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Prevention of the appearance of resistance to beta-lactam antibiotics in streptococcus pneumoniae: exploring strategies based on microbial ecology

Objectif



The classical ways to fight against bacterial pathogens start to be exhausted. During the last 20 years, not a single new family of antibiotics has arrived to the common clinical practice.
At the same time, the huge consumption of antibiotics (more than 1 ton/day in some european countries) is creating a deep alteration in normal microbial ecology, with a worldwide selection and spread of antibiotic resistant clones that require of innovative strategies to be controlled. Indeed pharmaceutical industry has created an environmental health problem. Vaccination against many respiratory pathogens may also have undesirable ecological consequences, Accordingly with the proposals of the new <>, measures to counteract environmental damage should be investigated and urgently applied. This Project was designed to explore some biotechnological possibilities based on microbial ecology, and focus one of the most relevant problems of current antibiotic therapy: infections caused by the ubiquitous Streptococcus pneumoniae. The microbial ecology of streptococcal populations remains poorly understood. It is critical to understand better the ecological-environmental factors regulating clonal selection, colonization, bacterial interference, and horizontal gene transfer. The study of these factors is the main goal of this Project, developing a collection of minimis ed Streptococcus genomes and exploring the fate of them in the animal model by the use of a marker (green fluorescent protein), and searching for colonization and horizontal gene transfer. New targets for non-antibiotic compounds interfering the acquisition of resistance, or biotherapeutic and bio-restaurative non-pathogenic strains may be found as a result of this Project.

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CSC - Cost-sharing contracts

Coordinateur

INSTITUTO NACIONAL DE LA SALUD
Contribution de l’UE
Aucune donnée
Adresse
KM 9.1,Crta.de Colmenar KM 9.1
28034 MADRID
Espagne

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Dernière mise à jour: 3 Mars 1999

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Permalink: https://cordis.europa.eu/project/id/BIO4980424/fr

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