Objective
The objective of this proposal is to define human herpesvirus 6 (HHV-6) and 7 (HHV-7) markers of reactivation and of overt infection and to develop immunologic and molecular diagnostic reagents that allow the early identification of patients at
risk of HHV-6-, and possibly HHV-7-associated disease.
(i) To analyse the function of HHV-6 104kDa immediate-early-1 (IEI-I) protein. IE-1 has been shown to be one of the very few genes that are transcribed at immediate-early times of infection. It is likely to play a key role in initiating HHV-6 lytic replication and thus the analysis of this protein will enlighten mechanisms of HHV-6 reactivation. As it is the only IE-protein of HHV-6 that bears no detectable homology to other known genes it will be an excellent marker for the switch from latency to reactivation.
(ii) To identify the glycoproteins predicted to be encoded in HHV-6 U21, U22, U23, and U47 genes. As these glycoproteins bear no detectable similarity to other herpesvirus or cellular glycoproteins, they are likely to enlight the mechanisms of virus interaction with the host cell and with the immune system, and will also serve as excellent markers.
(iii) To ascertain if immunodeficient conditions that lead to reactivation of HHV-6 also lead to reactivation of HHV-7;
(iv) To map the gene encoding the HHV-7 highly immunogenic phosphoprotein pp85 (v) To express the genes that appear to be markers of reactivation in procaryotic and eukaryotic systems, derive immunologic reagents.
(vi) To identify those pathologies and tissues with a high viral load and determine whether in these samples active infection can be probed for expression of the genes characterised above.
(vii) Final set-up of immunologic and molecular reagents that function as specific markers of viral reactivation or infection, and therefore enable the identification of pathological conditions associated with reactivation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pathology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
40126 Bologna
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.