Objective
Assessment of the long-term performance of bone implants in contact with body fluids and tissue materials with special regard to i.) events happening at the phase boundaries on a mo]ecular level, and, ii.) the cellular changes observable in these systems as a function of time leading to the establishment of test methods for biocompatibility and functionality of bone implant applications and of cell culture techniques as powerful tools for these types of investigations, the prediction of the long-term performance of implants in body environments, the verification of concepts of biomedical engineering and both the proposal for a Europan technical recommendation as well as a European data base of bone implant material interactions
Implant materials such as bone implants in orthopaedic and dental practice undergo degradation processes after implantation. This includes the release of certain amounts of dissolved or particulate implant components into the adjacent tissues. Particles, metal corrosion complexes and metal ions are suspected of producing an inflammatory response in the surrounding tissues. On reaching the blood stream or the respiratory system, even a systemic influence of those degradation products may be envisaged. Recent]y published studies have shown that degradation products even in low concentrations, released from commonly utilized materials might, on the basis of their broad spectrum of effects be an important factor in inflammation and inhibition of wound healing processes. Current discussions on implants present evidence that there is a need for a standardized, comparable and reliable testing scheme for materials provided for implantation with respect to their degradation reactions.
Aim of the present project is the establishment of in vitro testing methods to evaluate and predict the long-term performance of bone implant materials and to verify current concepts of biomedical engineering (including bone-bonding materials). Among the chosen materials will be metal alloys and bioactive glasses. Using in vitro conditions to simulate both short- and long-term clinical use, three principal aspects of biocompatibility (biointegration, biodegradation, biodissolution) will be studied. The testing methods will be based on modern techniques of especially cell and molecular biology. This should form the basis of a proposal for future discussions to delineate European standards on the biodegradation of materials and medical devices. Furthermore, data obtained from such testing methods shall act as positive input for the optimization of future implant materials.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology
- engineering and technology materials engineering amorphous solids
- medical and health sciences medical biotechnology implants artificial bone
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
55768 Hoppstädten-Weiersbach
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.