Objectif Assessment of the long-term performance of bone implants in contact with body fluids and tissue materials with special regard to i.) events happening at the phase boundaries on a mo]ecular level, and, ii.) the cellular changes observable in these systems as a function of time leading to the establishment of test methods for biocompatibility and functionality of bone implant applications and of cell culture techniques as powerful tools for these types of investigations, the prediction of the long-term performance of implants in body environments, the verification of concepts of biomedical engineering and both the proposal for a Europan technical recommendation as well as a European data base of bone implant material interactionsImplant materials such as bone implants in orthopaedic and dental practice undergo degradation processes after implantation. This includes the release of certain amounts of dissolved or particulate implant components into the adjacent tissues. Particles, metal corrosion complexes and metal ions are suspected of producing an inflammatory response in the surrounding tissues. On reaching the blood stream or the respiratory system, even a systemic influence of those degradation products may be envisaged. Recent]y published studies have shown that degradation products even in low concentrations, released from commonly utilized materials might, on the basis of their broad spectrum of effects be an important factor in inflammation and inhibition of wound healing processes. Current discussions on implants present evidence that there is a need for a standardized, comparable and reliable testing scheme for materials provided for implantation with respect to their degradation reactions.Aim of the present project is the establishment of in vitro testing methods to evaluate and predict the long-term performance of bone implant materials and to verify current concepts of biomedical engineering (including bone-bonding materials). Among the chosen materials will be metal alloys and bioactive glasses. Using in vitro conditions to simulate both short- and long-term clinical use, three principal aspects of biocompatibility (biointegration, biodegradation, biodissolution) will be studied. The testing methods will be based on modern techniques of especially cell and molecular biology. This should form the basis of a proposal for future discussions to delineate European standards on the biodegradation of materials and medical devices. Furthermore, data obtained from such testing methods shall act as positive input for the optimization of future implant materials. Champ scientifique medical and health sciencesclinical medicinepneumologyengineering and technologymaterials engineeringmedical and health sciencesmedical biotechnologyimplantsartificial bonenatural sciencesbiological sciencesmolecular biology Programme(s) FP4-BIOMED 2 - Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998 Thème(s) 2.4 - Rehabilitation, replacement or restoration of human function Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur Umwelt-Campus Birkenfeld Entwicklungs- und Management GmbH. Contribution de l’UE Aucune donnée Adresse .9935,Am Hasseld, Gabäude 55768 Hoppstädten-Weiersbach Allemagne Voir sur la carte Coût total Aucune donnée Participants (8) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire BIOMATECH S.A. France Contribution de l’UE Aucune donnée Adresse Rue Pasteur 115, Z.I. L'Islon 38670 CHASSE SUR RHONE Voir sur la carte Coût total Aucune donnée Bayerische Julius-Maximilians-Universität Würzburg Allemagne Contribution de l’UE Aucune donnée Adresse 2,JOSEF-SCHNEIDER-STR. 97080 WURZBURG Voir sur la carte Coût total Aucune donnée Costruzione e Gestione Dati Bioingegneria SpA Italie Contribution de l’UE Aucune donnée Adresse Viale dell' Industria 5 20070 Livraga Milano Voir sur la carte Coût total Aucune donnée Johannes Gutenberg Universität Mainz Allemagne Contribution de l’UE Aucune donnée Adresse 1,LANGENBECKSTR. 55101 MAINZ Voir sur la carte Coût total Aucune donnée Märkische Fachhochschule Iserlohn Allemagne Contribution de l’UE Aucune donnée Adresse 31,Frauenstuhlweg 58644 Iserlohn Voir sur la carte Coût total Aucune donnée UNIVERSITY OF LIVERPOOL Royaume-Uni Contribution de l’UE Aucune donnée Adresse L69 3BX LIVERPOOL Voir sur la carte Coût total Aucune donnée Università degli Studi di Roma Tor Vergata Italie Contribution de l’UE Aucune donnée Adresse Via Orazio Raimondo 135 00173 Roma Voir sur la carte Coût total Aucune donnée Université de Clermont-Ferrand II (Université Blaise Pascal) France Contribution de l’UE Aucune donnée Adresse 63177 Aubière Voir sur la carte Coût total Aucune donnée