Objective
The objective of the proposed project is the theoretical design, development, synthesis, and preclinical testing of improved high molecular weight paramagnetic complexes and nanoparticles resulting in positive perfusion agents. These compounds should remain almost exclusively in the intravascular space, selectively display the blood vessels, and be safely excreted preferably through the kidneys. They should possess a Tl relaxivity one or two orders of magnitude higher than those of low molecular weight gadolinium contrast agents. The main improvements over existing contrast agents are to be done in relaxivity, specificity, intravascular residence time, and biodistribution.
The project will cover the synthesis and the characterisation of new magnetic blood pool agents. This research will be twofold: on the one hand the efficiency (relaxivity) of the magnetic centre will be fine tuned by an extensive study of the factors governing the magnetic interactions between the water protons and the electron-rich centre and on the other hand the nature of the macromolecular (or particulate) carrier will be carefully examined in order to achieve the best blood half-life and guarantee the absence of any toxic effect. Among the microscopic parameters to be studied in the context of relaxivity improvement are the water exchange time between the magnetic centre and the bulk (tm) the field dependence of the electronic relaxation time (ts) and the molecular tumbling rates (tr). In particular the relationships between these factors and the molecular structure will be systematically studied and the influence of covalent and non-covalent binding to large size carriers will be evaluated.
This project involves two industrial partners. While a dedicated NMR field cycling instrumentation suited for routine relaxivity studies at medium and low fields will be developed with the first one, the collaboration with the other partner belonging to the pharmaceutical world will concern the evaluation of the in-vivo properties.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
7000 MONS
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.