Objectif To develop MR pulse sequences whereby perfusion, water diffusion, and metabolite concentrations can be quantified in human brain. Technical aims are to establish standard quality-assurance and clinical protocols and to evaluate the latter in multi-centre trials in normal controls and selected diseases. Clinical objectives are to apply these new techniques to normal developing and ageing human brain, Alzheimer's and multi-infarct dementias, and hypoxic and ischaemic disorders resulting in pathophysiological indices of importance for diagnosis and treatment monitoring.A better understanding of physiology and metabolism in normal, ageing and diseased brain may improve diagnosis and evaluation of new therapies in brain diseases which impose a large economic burden on health care systems and on society as a whole. The overall purpose of this project is to apply, in a collaborative multi-national programme, recent technical developments in magnetic resonance (MR) imaging of perfusion, diffusion and metabolism in the human brain to characterise: normal development and ageing processes, degenerative disorders and ischaemic and hypoxic disorders of the brain, in order to identify pathophysiological factors of importance for diagnosis and monitoring of treatment efficacy.The research programme involving ten competent European MR-centres, focuses on the development of a standard MR examination protocol for quantitative imaging of perfusion, diffusion and metabolism in the same investigation within a reasonable total examination time. Secondly, by means of this standard protocol in which the different MR-techniques are integrated, international multi-centre studies are launched in order to collect physiological, biochemical and clinical data characterising normal development, ageing processes and ischaemic, hypoxic brain diseases.The expected benefits of the proposed research programme are: to provide methods of non-invasive quantitative imaging of perfusion, diffusion and metabolism; to improve the understanding of biochemical and physiological behaviour of major brain diseases leading to improvements in prevention and therapy; to move from pre-clinical to clinical practice by incorporating multi-parameter MR-techniques; to facilitate the clinical evaluation and validation required by manufacturers in establishing new techniques; to provide common European standards for performance assessment and biomedical measurements; to utilise new MR-techniques to provide non-invasive measurements reducing the time scale, cost, complexity of developing and assessing new therapies including neuroprotective drugs. Champ scientifique medical and health sciencesbasic medicineneurologydementiaalzheimermedical and health sciencesbasic medicinephysiology Programme(s) FP4-BIOMED 2 - Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998 Thème(s) 2.2 - Imaging systems and other devices for diagnosis and therapy Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur Hvidovre University Hospital of København Contribution de l’UE Aucune donnée Adresse 30,Kettegård Alle 2650 Hvidovre Danemark Voir sur la carte Coût total Aucune donnée Participants (9) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Albert-Ludwigs-Universität Freiburg Allemagne Contribution de l’UE Aucune donnée Adresse 55,Hugstetterstraße 79106 Freiburg Voir sur la carte Coût total Aucune donnée Institut National de la Santé et de la Recherche Médicale France Contribution de l’UE Aucune donnée Adresse 38043 Grenoble Voir sur la carte Coût total Aucune donnée Max-Planck-Gesellschaft zur Förderungder Wissenschaften e.V. Allemagne Contribution de l’UE Aucune donnée Adresse 22-26,Inselstraße 04103 Leipzig Voir sur la carte Coût total Aucune donnée Technische Universiteit Delft Pays-Bas Contribution de l’UE Aucune donnée Adresse 1,Lorentzweg 2628 CJ Delft Voir sur la carte Coût total Aucune donnée UNIVERSITY COLLEGE LONDON Royaume-Uni Contribution de l’UE Aucune donnée Adresse Capper Street 11-20 WC1E 6JA LONDON Voir sur la carte Coût total Aucune donnée UNIVERSITY OF VIENNA Autriche Contribution de l’UE Aucune donnée Adresse 13,Waehringer Strasse 13 1090 WIEN Voir sur la carte Coût total Aucune donnée United Medical and Dental Schools of Guy's and St Thomas's Hospitals Royaume-Uni Contribution de l’UE Aucune donnée Adresse St Thomas's Street London Bridge SE1 9RT London Voir sur la carte Coût total Aucune donnée Università degli Studi di Bologna Italie Contribution de l’UE Aucune donnée Adresse Via Massarenti 9 40138 Bologna Voir sur la carte Coût total Aucune donnée Universität Bremen Allemagne Contribution de l’UE Aucune donnée Adresse 1,Bibliothekstrasse 28334 Bremen Voir sur la carte Coût total Aucune donnée
