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Endoscopic access to the feto-placental unit: from animal experiments to clinical applications

Exploitable results

Although the amnio-insufflator is technically satisfying, its clinical use is hampered by the observation that CO2 affects fetal acid-base status (reference 1). Recent observations have questioned the concern for fetal hypercapnia and acidosis (reference 2), but the research consortium wants to investigate this further prior to clinical implementation (reference 3). References: 1 F Luks, J Deprest, M Marcus, J Vertommen, K Vandenberghe, T Lerut, I Brosens. Carbon dioxide pneumamnios causes acidosis in the fetal lamb. Fetal Diagnosis and Therapy, 1994, 9, 105-109. 2. Saiki Y, Litwin DEM, Bigras JL, et al. (1997). Reducing the deleterious effects of intrauterine CO2 during fetoscopic surgery. J Surg Res, 69: 51-54. . 3. Bruner JP,Richards WO, Tulipan NB, Arney TL, Zaner RM (1999). Endoscopic coverage of fetal myelomeningocele in utero. Am J Obstet Gynecol, in press.

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