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Identification of susceptibility genes in multiple sclerosis

Objective

To identify genes with an importance for susceptibility, resistance and disease course in multiple sclerosis, thereby increasing the understanding of the underlying pathogenetic events.

The project consists of the following tasks:

The identification, collection and clinical and physical characterization of a clinical MS material gathered from an ethnically very homogenous background.
A genome-wide search of 390 polymorphic DNA markers spanning the entire genome in 100 affected sibling pairs. Confirmation of the importance of identified chromosomal segments will be sought in an additional 100 multicase families.
Selected candidate genes, based on presumed pathogenetic mechanisms, will be studied directly in the sib-pairs and confirmed in the multicase families.
Selected genes or chromosomal regions, previously implicated or identified within the project, will be investigated in a very large number (500-1000) of sporadic MS patients for the delineation of associated haplotypes.
Parallel and subsequent analysis of an ethnically more distant reference population.

This project offers a unique opportunity in this type of analysis due to the ethnic similarities between the Scandinavian populations rendering a, sufficiently large, homogeneous, study population, likely to yield a high power of resolution in the analysis of a polygenic disorder. At completion, the project is likely to have identified a number of genes or delineated chromosomal regions containing genes, with a role in pathogenetic mechanisms in MS.

Coordinator

KAROLINSKA INSTITUTE
Address
Huddinge University Hospital
141 86 Huddinge
Sweden

Participants (7)

Københavns Universitet
Denmark
Address
20,Tagensvej
2200 København
Lund University
Sweden
Address

221 85 Lund
Servizio Andaluz de Salud
Spain
Address
S/n,avenido Carlos Haya
29010 Malaga
UNIVERSITY OF BERGEN
Norway
Address
Haukeland Hospital
5021 Bergen
UNIVERSITY OF OSLO
Norway
Address
27,Pilestredet 32 Rikshospitalet
0027 Oslo
UNIVERSITY OF TURKU
Finland
Address
13,Kiinamyllynkatu 13
20520 Turku
University of Gøteborg
Sweden
Address
Sahlgrenska Sjuhkuset
413 45 Gøteborg