Objective
Several novel formulations of perfluorocarbon-based emulsions for use as respiratory gas-carrying fluids were developed and evaluated in relevant biological systems, including specially-developed in vitro bioassays. Some of the new emulsions incorporated novel and highly-purified fluoro-surfactants and newly-synthesised fluorinated stabilisers which significantly improved emulsion stability and increased storage time. The emulsions were steam sterilisable and storable at room temperature for over 1 year. In vivo gross toxicity assessments of selected emulsions at clinically-relevant doses showed satisfactory results. Some emulsions were assessed as perfusates of isolated vertebrate organs, where ex-vitro vital functions were markedly improved. Some of the novel fluoro-surfactants inhibited human platelet aggregation in vitro in a dose-dependent manner, suggesting novel and clinically-important potential applications as anti-thrombotic agents.
The proposed research is directed at developing an oxygen-carrying system based on perfluorocarbon emulsified in physiological saline solution. It will provide enhanced medical care in cases of surgery, organ transplantation, diagnostic and emergency. The oxygen-carrying system will be characterized by improved long term storability at ambient and body temperature (emulsions of third generation) and by tailor made composition and quality for special applications. The major research tasks are:
(i) Development of perfluorocarbons of improved emulsifiability and aspiration rates.
(ii) Improvement of perfluorocarbon emulsifiability through cosurfactants (semifluorinated hydrocarbons or heterocyclic perfluorinated hydrocarbons) which reduce interfacial forces.
(iii) Development of appropriate fluorosurfactants which reduce particle size growth.
(iv) Design and development of tailor made perfluorocarbon emulsions for special application areas.
(v) Development of toxicity and biocompatibility criteria by combining cell culture tests and animal experiment (to reduce number of animal experiments).
Successful completion would provide improved transfusion media (enhanced oxygen transport to tissue), diagnostic tools (imaging tornography, sonography), oxygenating media for transplantation surgery (transport and long term storage of organs) and natural blood substitutes in developing countries.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- natural sciences chemical sciences organic chemistry hydrocarbons
- medical and health sciences clinical medicine transplantation
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
89069 Ulm
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.