Objective
1. Capillary tubes made of Polymethylpentene with good binding properties and low background fluorescence. Transparency and surface smoothness acceptable but not of optical quality.
2. Development of biocompatible photoresist and lithographic processes for wide use patterning of biomolecules through the lift-off technique.
3. Development of photo grafting patterning of the capillaries using aminogroup photoreagents.
4. Development of discrete capillary bands by syringe injection of biomolecules.
5. Complete capillary multiband immunosensor tested against clinical and environmental analytes.
A new type of an optical immunosensor that holds the promise of inexpensive fast and sensitive multianalyte assays is proposed. It can be used for both clinical and environmental applications. The devices are based on the capillary geometry and are made of
inexpensive materials such as polystyrene, polymethylmethacryiate (PMMA) or polycarbonate. The inner surface of the capillaries is properly functionalized through biological and photochemical techniques to allow coating of different bands with different biomolecules. The capillary geometry facilitates such a partition which provides for multianalyte determinations. The multianalyte feature is a major point of this proposal since the simultaneous determination of relevant analytes cuts assay cost and time, while the capillary geometry substantially suppresses the required reagent and sample volumes.
Another major point of this proposal is the function of the capillary as an optical fiber guiding the light emitted by each band to its ends where a detector is placed. The instrumentation required for excitation and detection is quite simple. It consists of a pulsed light source of appropriate wavelength and a silicon detector followed by the low noise analog front end electronics and a digitizer. In conclusion, the proposal aims at adding value to inexpensive polymers through proper geometry and surface functionalization so that they can be used as immunosensors in large scale clinical and environmental applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering fibers
- natural sciences biological sciences biochemistry biomolecules
- engineering and technology materials engineering amorphous solids organic amorphous solids
- engineering and technology materials engineering coating and films
- natural sciences mathematics pure mathematics geometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
15310 ATHENS
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.