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Development of novel matrices and encapsulatory materials for support and modulation of hair follicle growth

Objective



Objectives and content
The skin is the largest organ of the human body and there
is an enormous market (56 billion ECU) in pharmaceuticals
and cosmetics targeted to it. A major goal of both the
cosmetic and pharmaceutical industries is to develop in
vitro models of the skin that accurately reflect the in
vivo state and that can be used for both basic research
and also to develop and screen novel actives and targeted
delivery systems. Current models do not fully reflect
the in-vivo situation and there is a clear need for new
models. The Partners propose the development of novel
scaffolds and matrices that will support the in-vitro
maintenance of histocultured human skin as well as
isolated human pilosebaceous units (PSUs) and hair
follicles. In addition their suitability as matrices for
developing synthetic organs/tissues capable of supporting
hair follicle and skin gland neogenesis will be
investigated.
Through concertation of their expertise the four
partners, QMWC, L'OREAL, FAB and HUB will bring the
following innovations to the field of tissue engineering:
The first rationally designed, smart dermal matrices
which will: - release growth factors - be biocompatible
with epidermal matrices - support proliferation and
differentiation of PSUs The first use of hyaluronic acidbased polymers and/or methacrylate/phthalate-based viscoelastic entanglement gels for the support of
proliferation, differentiation and cycling of hair
follicles or PSUs.
The first combination of wholly synthetic dermal and
epidermal matrices with appropriate cell populations to
create an hairy skin-equivalent The first use of
simultaneous beta-imaging and light microscopy for the
analysis of active delivery to the hair follicle or PSU
The proof-of-principle that actives can be directly
delivered to specific target cell populations in the PSU
Exploitation plans include development, marketing and
sales of products as diverse as new actives for removing
unwanted hair, graftable hairy skin, and a hairy-skin
equivalent to replace animals in cosmetic testing.

Coordinator

QUEEN MARY AND WESTFIELD COLLEGE - ST. BARTHOLOMEWS & THE ROYAL LONDON SCHOOL OF MEDICINE & DENTISTRY
Address
2,Newark Street 2
E1 2AT London
United Kingdom

Participants (4)

ISO TIS N.V.
Netherlands
Address
10,Prof. Bronkhorstlaan 10-D
3723 MB Bilthoven
L'Oréal SA
France
Address
90,Rue Du Général Roguet
92110 Clichy
LABORATOIRE D'EVALUATION DES MATÉRIELS IMPLANTABLES
France
Address
Technopole Montesquieu
33650 Martillac
UNIVERSITY OF HAMBURG
Germany
Address
52,Martinistrasse 52
20246 Hamburg