Objective
1) Alterations of heme metabolism in leucocytes as biomarker of exposure to diesel exhaust (ESTONIA)
The aim of this proposed project is the investigation of correlations between the alterations in heme biosynthesis and interaction of heme with DNA in leucocytes of workers exposed to diesel exhaust and the investigation of correlation between these changes of heme metabolism and the degree of exposure. This research will assist in identifying biochemical markers specific for diesel exhaust exposures in man. 2) DNA repair in mammalian cells damaged to chemicals which occur in diesel exhaust emissions (SLOVAKIA)
The aim of the project is to define the level of DNA, the mechanism of action and of some pahs and nitro pahs which are frequent in diesel engine exhaust. Attention will also be concentrated on DNA repair and induction of gene mutations and morphological transformation in mammalian cells. Cytochrome P450 plays a crucial role in the metabolic activation of many xenobiotics, including PAHs. Their role in the metabolic activation of nitro-pahs will also be studied.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
YO1 5DD York
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.