Objective
THE LONG TERM OF THE WORK IS TO:
(A) PRODUCE A VIABLE ECONOMIC PROCESS FOR THE PRODUCTION OF FERMENTABLE GLUCOSE USING THE EXTRACELLULAR ENZYMES ELABORATED BY RUMEN ANAEROBIC FUNGI WHICH HAVE BEEN ISOLATED RECENTLY AT THE ROWETT INSTITUTE;
(B) IMPROVE THE EFFICIENCY OF THE DIRECT FERMENTATION OF THE CELLULOSE TO ETHANOL BY THE ANAEROBIC BACTERIUM CLOSTRIDIUM THERMOCELLUM; IMPROVE THE HYDROLYSIS OF CELLULOSE TO GLUCOSE USING C.THERMOCELLUM CELLULASE ALONE OR IN COMBINATION WITH THE CELLULASES OF OTHER CELLULOLYTIC MICROORGANISMS.
ALL OF THESE ASPECTS OF THE WORK INVOLVE STUDIES ON THE BASIC MECHANISM OF CELLULASE ACTION, AND THIS APPROACH IS BEING USED IN THE BELIEF THAT REALISATION OF THE FULL POTENTIAL OF THE CELLULASES OF THESE MICROORGANISMS IS DEPENDENT ON A GOOD UNDERSTANDING OF THE INTERACTIONS BETWEEN THE VARIOUS ENZYMES THAT COMPRISE THE CELLULASE SYSTEMS.
IT HAS BEEN ESTABLISHED THAT THE EXTRACELLULAR CELLULASE OF THE ANAEROBIC RUMEN FUNGUS NEOCALLIMASTIX FRONTALIS IS REMARKABLE IN ITS CAPACITY FOR EFFECTING THE BREAKDOWN OF CRYSTALLINE CELLULOSE. INDEED, IN COMPARATIVE TESTS CARRIED OUT BY THE AUTHORS, HTIS CELLULASE WOULD APPEAR TO BE MORE ACTIVE THAN THE CELLULASE OF THE FUNGUSTRICHODERMA REESEI, WHICH IS BEING STUDIED WORLD WIDE FOR ITS COMMERCIAL POTENTIAL FOR CONVERTING CELLULOSIC WASTE TO FERMENTABLE GLUCOSE. FRACTIONATION AND OTHER STUDIES ON THE EXTRACELLULAR CELLULASE OF N.FRONTALIS HAVE SHOWN IT TO CONTAIN ENDO-1, 4-BETA-GLUCANASE, BETA-GLUCOSIDASE AND OTHER FACTOR. PRELIMINARY TESTS WOULD SUGGEST THAT THE OTHER FACTOR IS A CELLOBIOHYDROLASE, AND THAT THIS MAY EXIST AS A COMPLEX WITH SOME ENDO-1,4-BETA-GLUCANASE AND BETA-GLUCOSIDASE ENZYMES. FUTURE WORK WILL CONCENTRATE ON ESTABLISHING THE REASONS FOR THE HIGH ACTIVITY OF THE CELLULASE OF RK21 ON CRYSTALLINE CELLULOSE.
THE WORK ON C.THERMOCELLUM IS PRESENTLY DIRECTED TOWARDS A COMPARISON OF THE EXTRACELLULAR CELLULASE ACTIVITY PRODUCED BY DIFFERENT STRAINS OF THE BACTERIUM GROWN IN DIFFERENT MEDIA.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences microbiology mycology
- natural sciences chemical sciences organic chemistry alcohols
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- engineering and technology industrial biotechnology bioprocessing technologies fermentation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
AB21 9SB ABERDEEN
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.