Objective
1) ELABORATION AND COMPARATIVE EVALUATION OF TEST SYSTEMS FOR THE ASSESSMENT OF GENETIC EFFECTS OF ENVIRONMENTAL CHEMICALS AND OF THE PRODUCTS OF THEIR METABOLIC TRANSFORMATION.
2) ASSESSMENT OF THE MUTAGENIC POTENTIAL OF DIESEL EXHAUSTS.
THE CONTRACT COVERS TWO PROJECTS:
1) IMPROVEMENT OF THE METHODOLOGY AND VALIDATION OF TESTS FOR MUTAGENIC ACTIVITY AND TRANSFORMATION TESTS.
THE OBJECTIVES OF THE PROJECT ARE TO PERFORM COMPARATIVE STUDIES BETWEEN MUTAGENIC AND TRANSFORMING EFFECTS OF ENVIRONMENTAL CHEMICALS AND SIMULTANEOUSLY TO CONTRIBUTE TO THE VALIDATION OF THE CELL TRANSFORMATION SYSTEM.
FOR THE TRANSFORMATION EXPERIMENTS TWO CELL TYPES WILL BE USED: SYRIAN HAMSTER EMBRYO CELLS (SHEC) WHICH METABOLISE ALMOST ALL KNOWN CARCINOGENS AND THE C3H/10T/1/2 ESTABLISHED CELL LINE METABOLISING ONLY PAH. THE CRIRETTERIA FOR THE EVALUATION OF THE EFFECTS ARE THE FORMATION OF FOCI AND THE FORMATION OF ABNORMAL COLONIES.
FOR THE EVALUATION OFTHE MUTAGENIC THE V-79 ESTABLISHED CHINESE HAMSTER CELL LINE WILL BE USED; THE INDUCTION OF MUTANTS, 6-THIOGUANIN RESISTANTS AND THE SCE WILL BE THE CRITERIA, COMPLEMENTED BY THE IN VIVO MICRONUCLEUS TEST..
2) MUTAGENIC AND CARCINOGIC EFFECTS OF DIESEL EXHAUSTS.
IN THIS PROJECT THE IN VITRO AND IN VIVO MUTAGENIC AND CARCINOGENIC POTENTIAL OF DIESEL PARTICULATES AND EXTRACTS USING SERUM AND ACETONE AS VEHICLES WILL BE STUDIED.
THE MUTAGENIC EFFECT WILL BE STUDIED USING V-79 CELLS FOR SCES ANS TGR INDUCTION IN VITRO, AND THE MICRONUCLEUS TEST IN MICE OR/AND IN CHINESE HAMSTER.
THE CARCINOGENIC EFFECT WILL BE EVALUATED
- IN VITRO, USING THE SYRIAN HAMSTER EMBRYO CELLS AND C3H/10T1/2 CELLS
- IN VIVO, INOCULATING SUB-CUTANEOUSLY THE PARTICULATES WITH OR WITHOUT VEHICLE.
AT A LATER STAGE, THE CARCINOGENIC EFFECT OF SOME SPECIFIC COMPONENTS OF THE DIESEL EXHAUST WILL BE STUDIED.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
94802 Villejuif
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.