DOSE AND EFFECT INDICATORS OF ENVIRONMENTAL EXPOSURE TO ARSENIC AND VANADIUM

Objective

1) TO FURTHER DEVELOP ANALYTICAL TECHNIQUES FOR THE BIOLOGICAL MONITORING OF EXPOSURE TO ARSENIC AND TO VANADIUM
2) TO ELUCIDATE THE RELATIONSHIPS BETWEEN ENVIRONMENTAL EXPOSURE AND INTERNAL DOSE, AND BETWEEN INTERNAL DOSE AND EFFECTS.

FOR ARSENIC, INVESTIGATIONS OF:

1) THE INFLUENCE OF ARSENIC ON THE BIOSYNTHETIC PATWAY OF HEME AND THE METABOLISM OF PORPHYRINS IN ANIMALS,

2) THE PERFORMANCE OF THE PERIPHERAL NERVOUS SYSTEMS IN ANIMALS AND MAN, AFTER CHRONIC LOW-DOSE EXPOSURE TO AS2O3,

3) THE RELATIONSHIP BETWEEN INTERNAL DOSE INDICATORS OF ARSENIC AND RENAL TUBULAR FUNCTIONS.

FOR VANADIUM:

1) DEVELOPMENT OF ANALYTICAL PROCEDURES FOR MEASUREMENT OF VANADIUM BY ATOMIC ABSORPTION SPECTROMETRY, WITH SPECIAL ATTENTION TO VANADIUM ANALYSIS IN BIOLOGICAL SAMPLES (BLOOD, URINE, HAIR),

2) INVESTIGATION OF THE RELATIONSHIP BETWEEN ENVIRONMENTAL (AND OCCUPATIONAL) EXPOSURE AND INTERNAL DOSE.

Programme(s)

PRE-ENVPROT 3C - Sectoral research and development programme (EEC) in the field of environment (environmental protection and climatology) - indirect and concerted actions - Environmental protection -, 1981-1985

Topic(s)

Data not available

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Università degli Studi di Milano

EU contribution

No data

Address

Via Santa Barnaba 8
20122 Milano
Italy

Total cost