Objective TO ELUCIDATE THE MECHANISMS OF ACTION OF VARIOUS HEAVY METALS ON THE CENTRAL NERVOUS SYSTEM AND TO INVESTIGATE SYNERGISMS AND/OR ANTAGONISMS IN EFFECTS. /THE FOLLOWING EXPERIMENTAL GROUPS ARE INVESTIGATED: 1) PB+CO: THE INTERACTION OF LOW LEVELS OF LEAD CARBON MONOXIDE ARE FOLLOWED IN NEW-BORN RATS, WHOSE MOTHERS HAD BEEN GIVEN LEAD FOR 60 DAYS PRIOR TO PREGNANCY, THROUGHOUT PREGNANCY AND FOR 90 DAYS AFTER BIRTH. CO IS ADMINISTERED CONTINUOUSLY THROUGHOUT THE PREGNANCY; 2) PB+CD: THE INTERACTION OF LEAD AND CADMIUM IS STUDIED IN RATES; 3) JUVENILE MONKEYS ARE EXPOSED TO LEAD LEVELS; 4) THE POTENTIAL BENEFICIAL EFFECTS OF ZINC IS STUDIED IN RATS GIVEN HIGH DOSES OF LEAD; 5) RATS EXPOSED TO LOW DOSES OF LEAD FROM BIRTH UNTIL LATE ADULTHOOD. AFTER SACRIFICE, A NUMBER OF UNTRASTRUCTURAL, MORPHOMETRICAL AND BIOCHEMICAL PARAMETERS ARE STUDIED. Programme(s) PRE-ENVPROT 3C - Sectoral research and development programme (EEC) in the field of environment (environmental protection and climatology) - indirect and concerted actions - Environmental protection -, 1981-1985 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator BELGIAN NUCLEAR RESEARCH CENTRE EU contribution No data Address 200,Herrmann Debrouxlaan 40-42 1160 BRUXELLES Belgium See on map Total cost No data
