Objective
ELABORATION AND COMPARATIVE EVALUATION OF TEST SYSTEMS FOR THE ASSESSMENT OF GENETIC EFFECTS OF ENVIRONMENTAL CHEMICALS AND OF THE PRODUCTS OF THEIR METABOLIC TRANSFORMATION.
THE PROJECT AIMS AT ASSESSING POTENTIAL RISKS TO HUMAN HEALTH FROM PRENATAL EXPOSURE TO GENOTOXIC ENVIRONMENTAL CHEMICALS BY SHORT-TERM TESTS (MICRONUCLEUS, SISTER CHROMATID EXCHANGE, GENE MUTATION). THESE WILL BE APPLIED PRECISELY DEFINED CELL TYPES AND TAKE ACCOUNT OF THE PARTICULAR CELL-AND ORGAN-SPECIFIC EFFECTS OBSERVED FROM LONG TERN TRANSPLACENTRAL CARCINIGENESIS ANIMAL STUDIES AND INDICATED BY EPIDEMIOLOGY OF HUMAN CHILDHOOD CANCER. PARTICULAR ATTENTION WILL BE GIVEN TO BLOOD, AND LYMPHOID CELLS, AND THE DEVELOPING BRAIN. THE ACTIVITIES OF POTENTIALLY GENOTOXIC ENVIRONMENTAL CHEMICALS IN THESE IN VIVO/IN VITRO ASSAYS WILL BE COMPARED WITH THEIR MUTAGENIC POTENTIAL MEASURED BY SPECIFIC LOCUS IN VITRO ASSAYS BASED ON MOUSE LYMPHOMA L518Y CELLS, AND HUMAN LYMPHOBLASTOID CELLS, COUPLED TO CELL MEDIATED METABOLIC ACTIVATION SYSTEMS, INCLUDING THOSE DERIVED FROM PRENATAL ORGANS. EXPERIMENTS IN ALL THESE SYSTEMS WILL BE DESIGNED TO ENABLE CORRELATION TO BE MADE BETWEEN "GENETIC" END POINTS AND MOLECULAR LESIONS IN DNA AND CHROMATIN.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BN1 9RH Brighton
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.