Objective DEVELOPMENT AND VALIDATION OF METHODS TO IDENTIFY NON-GENOTOXIC CARCINOGENS. THE MECHANISMS OF CELL TRANSFORMATION ARE STUDIED WITH A NUMBER OF CELL SYSTEMS USING MUTAGENIC AND NON-MUTAGENIC CHEMICALS. THE BIOLOGICAL, ENZYMATIC AND GENETIC END-POINTS ARE COMPARED. IN PARTICULAR, THE FOLLOWING TYPES OF STUDIES ARE CARRIED OUT: I) PREDICTABILITY OF MUTAGENICITY-CARCINOGENICITY AND SHORT TERM SKIN TEST: MUTAGENS ALREADY STUDIED IN THE PROGRAMME AND A NUMBER OF RECOGNIZED PROMOTERS ARE TESTED IN VARIOUS MUTAGENICITY AND SHORT TERM SKIN ASSAYS. THEIR CARCINOGENIC POTENTIAL IS PREDICTED AND VERIFIED IN A LONG TERM SKIN TEST. II) STUDY OF THE RESPONSE TO MUTAGENS/CARCINOGENS OF SENSITIVE AND RESISTANT STRAINS OF MICE: THE WORK INCLUDES CYTOGENETIC ANALYSIS IN BLOOD LYMPH AND EPIDERMAL CELLS. III) VALIDATION AND DEVELOPMENT OF IN-VITRO CELL TRANSFORMATION SYSTEMS : VALIDATION OF BALB/3T3 MOUSE CELL LINE AND SYRIAN HAMSTER EMBRYO CELLS. THE POTENTIAL OF THESE CELL SYSTEMS TO DETECT VARIOUS CLASSES OF CARCINOGENS WILL BE IMPROVED. Fields of science natural sciencesearth and related environmental sciencesenvironmental sciencespollutionmedical and health sciencesclinical medicineembryology Programme(s) FP1-ENVPROT 4C - Multiannual research and development programmes (EEC) in the field of the environment - Protection of the environment -, 1986-1990 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator Centre National de la Recherche Scientifique (CNRS) Address 7 rue guy môquet 94802 Villejuif France See on map EU contribution € 0,00
