Skip to main content

Comparative research on endocrine disrupters - phylogenetic approach and common principles focussing on androgenic/antiandrogenic compounds

Objective

COMPRENDO as an interdisciplinary, integrated approach addresses endocrine disruption in human and wildlife species, focussed on androgenic/antiandrogenic compounds (AACs). The project will identify human and environmental exposures to AACs. A variety of human-relevant models (cell lines, tissues, rodents) and wildlife species (amphibians, fish, echinoderms, crustaceans, molluscs) will be exposed to 13 chemicals and various environmental samples to develop new biological effect measures, including a molecular screen for genomic AAC effects. Common principles of AAC action will be identified and new models for the extrapolation on human health developed. Lab cultures of suitable invertebrates will be established and their baseline endocrinology analysed, facilitating the use of these species as standard test organisms. Finally, an evaluation of the risk originating from AACs for humans and wildlife will be performed.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT
Address
Siesmayerstrasse 70
60054 Frankfurt Am-main
Germany

Participants (13)

BRUNEL UNIVERSITY
United Kingdom
Address
Kingston Lane
Uxbridge
Bureau de Recherches Geologiques et Minieres
France
Address
Avenue Claude Guillemin 3
45060 Orleans
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Jordi Girona 18-26
08034 Barcelona
FORSCHUNGSVERBUND BERLIN E.V.
Germany
Address
Mueggelseedamm 310
12587 Berlin
LABORATORY FOR FRESHWATER/MARINE RESEARCH AND COMPARATIVE PATHOLOGY - LIMNOMAR
Germany
Address
Bei Der Muenze 11
22145 Hamburg
LUND UNIVERSITY
Sweden
Address
Helgonavaegen 3B
223 62 Lund
ORLOWO-2
Poland
Address
Szafranowa 12 D/27
81 591 Gdynia
TECHNICAL UNIVERSITY OF DENMARK
Denmark
Address
Building 115 Bygningstorvet
2800 Lyngby
THE UNIVERSITY OF MILANO
Italy
Address
Via Celoria 26
20133 Milano
UNIVERSITY OF BONN MEDICAL CENTER
Germany
Address
Sigmund-freud-strasse 25
53105 Bonn
UNIVERSITY OF EXETER
United Kingdom
Address
Prince Of Wales Road
EX4 4PS Exeter
UNIVERSITY OF GDANSK
Poland
Address
Sobieskiego Str. 18
80 952 Gdansk
UNIVERSITY OF IOANNINA
Greece
Address
1,Panepistimioupolis 1
45110 Ioannina