Comparative research on endocrine disrupters - phylogenetic approach and common principles focussing on androgenic/antiandrogenic compounds

Objective

COMPRENDO as an interdisciplinary, integrated approach addresses endocrine disruption in human and wildlife species, focussed on androgenic/antiandrogenic compounds (AACs). The project will identify human and environmental exposures to AACs. A variety of human-relevant models (cell lines, tissues, rodents) and wildlife species (amphibians, fish, echinoderms, crustaceans, molluscs) will be exposed to 13 chemicals and various environmental samples to develop new biological effect measures, including a molecular screen for genomic AAC effects. Common principles of AAC action will be identified and new models for the extrapolation on human health developed. Lab cultures of suitable invertebrates will be established and their baseline endocrinology analysed, facilitating the use of these species as standard test organisms. Finally, an evaluation of the risk originating from AACs for humans and wildlife will be performed.

Programme(s)

• FP5-EESD - Programme for research, technological development and demonstration on "Energy, environment and sustainable development, 1998-2002"

Topic(s)

• 1.1.4.-1. - Key action Sustainable Management and Quality of Water

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT

Address

Siesmayerstrasse 70
60054 Frankfurt Am-main
Germany

Participants (13)

BRUNEL UNIVERSITY

United Kingdom

Address

Kingston Lane
Uxbridge

Bureau de Recherches Geologiques et Minieres

France

Address

Avenue Claude Guillemin 3
45060 Orleans

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

Address

Jordi Girona 18-26
08034 Barcelona

FORSCHUNGSVERBUND BERLIN E.V.

Germany

Address

Mueggelseedamm 310
12587 Berlin

LABORATORY FOR FRESHWATER/MARINE RESEARCH AND COMPARATIVE PATHOLOGY - LIMNOMAR

Germany

Address

Bei Der Muenze 11
22145 Hamburg

LUND UNIVERSITY

Sweden

Address

Helgonavaegen 3B
223 62 Lund

ORLOWO-2

Poland

Address

Szafranowa 12 D/27
81 591 Gdynia

TECHNICAL UNIVERSITY OF DENMARK

Denmark

Address

Building 115 Bygningstorvet
2800 Lyngby

THE UNIVERSITY OF MILANO

Italy

Address

Via Celoria 26
20133 Milano

UNIVERSITY OF BONN MEDICAL CENTER

Germany

Address

Sigmund-freud-strasse 25
53105 Bonn

UNIVERSITY OF EXETER

United Kingdom

Address

Prince Of Wales Road
EX4 4PS Exeter

UNIVERSITY OF GDANSK

Poland

Address

Sobieskiego Str. 18
80 952 Gdansk

UNIVERSITY OF IOANNINA

Greece

Address

1,Panepistimioupolis 1
45110 Ioannina