Objective
COMPRENDO as an interdisciplinary, integrated approach addresses endocrine disruption in human and wildlife species, focussed on androgenic/antiandrogenic compounds (AACs). The project will identify human and environmental exposures to AACs. A variety of human-relevant models (cell lines, tissues, rodents) and wildlife species (amphibians, fish, echinoderms, crustaceans, molluscs) will be exposed to 13 chemicals and various environmental samples to develop new biological effect measures, including a molecular screen for genomic AAC effects. Common principles of AAC action will be identified and new models for the extrapolation on human health developed. Lab cultures of suitable invertebrates will be established and their baseline endocrinology analysed, facilitating the use of these species as standard test organisms. Finally, an evaluation of the risk originating from AACs for humans and wildlife will be performed.
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
60054 Frankfurt Am-main
Germany
Participants (13)
Uxbridge
45060 Orleans
08034 Barcelona
12587 Berlin
22145 Hamburg
223 62 Lund
81 591 Gdynia
2800 Lyngby
20133 Milano
53105 Bonn
EX4 4PS Exeter
80 952 Gdansk
45110 Ioannina