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CONTROL OF CLASSICAL SWINE FEVER BY MOLECULAR DIAGNOSIS AND EPIDEMIOLOGY

Objective



Background :

Despite intensive efforts, it has not proved possible to eradicate classical swine fever
(CSF) in Europe and new outbreaks of the disease continue to occur within EU member states and Eastern Europe. Not only the direct costs but also the indirect costs, relating to international trade of both live pigs and pig products, of these outbreaks are enormous. In order to deal with outbreaks, there is a short term need for improved diagnosis and a longer term need for a better understanding of why the disease is reappearing.

The objective is :

This research proposal seeks to address both the need for improved CSF diagnosis and the need for identifying the routes of continuing disease spread. The former will be dealt with through the development, optimisation and harmonised validation of new diagnostic methods based on detection of CSF virus antigens and RNA; the latter through the development of molecular epizootiological methods to permit the origin and spread of outbreaks to be more precisely determined.

Short description of the project :

As regards diagnostic tests, particular emphasis will be placed on establishing tests based on reverse transcription - polymerase chain reaction (RT-PCR) for screening blood samples of live pigs and tissue from abattoir carcasses. Molecular epidemiology will be based on the establishment of a specific fingerprint for each outbreak that will be compared to others in order to determine the likely patterns of the spread.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

MAFF Central Veterinary Laboratory
Address
Woodham Lane New Haw Addlestone
KT15 3NB Weybridge
United Kingdom

Participants (6)

HANNOVER VETERINARY SCHOOL - TIERARZTLICHE HOCHSCHULE HANNOVER
Germany
Address
Buentenweg, 17
30559 Hannover
INSTITUTE OF VIROLOGY AND IMMUNOPROPHYLAXIS
Switzerland
Address

3147 Mittelhausern
Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche
Italy
Address
Via G. Salvemini 1
06126 Perugia
NATIONAAL INSTITUUT VOOR DIERGENEESKUNDIG ONDERZOEK
Belgium
Address
Groeselenberg, 99
1180 Bruxelles
NATIONAL VETERINARY INSTITUTE
Sweden
Address
Husargatan, 3
751 23 Uppsala
THE NATIONAL VETERINARY INSTITUTE
Poland
Address
Al.partyzantow, 57
24-100 Pulawy