Design of synthetic (peptide) molecules that mimic the binding sites ligand and receptor or antigen and antibody)
For canine parvovirus a peptide was defined, using PEPSCAN, which is able to induce full protection in the target animal (ie canines and mink). This is the first example of a fully synthetic vaccine able to induce full protection. The same peptide was used to be exposed on a recombinant plant virus (CPMV). This recombinant plant virus was shown to protect the target animal fully against disease. As such this is the first plant produced vaccine that is shown to protect the target animal.