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BIOMARKERS OF EXPOSURE AND EFFECT IN RELATION TO QUALITY OF LIFE AND HUMAN RISK ASSESSMENT

Objective



The objectives of this project are to develop biomarker approaches to provide information on beneficial and deleterious dietary combinations in relation to human health. In order to achieve this objective it is necessary to :

- determine which biomarker approaches are presently being used throughout
Europe;
- decide what are the major health related issues and endpoints which must be
considered;
- consider the relative merits of approaches based upon biomarkers of exposure
and of biological effect;
- delineate the interplay of deleterious and beneficial dietary components;
- carry out co-operative trials where possible to prioritise and assess the area;
- to identify and prioritise research areas in the field of biomarkers which are
suitable for future shared cost research.

Clearly biomarkers have a role in the interpretation of the interaction between diet and health and this proposal seeks to determine the most efficient and relevant biomarkers which relate to human health and to define the pace and direction of future studies. This information will be of benefit both to consumers throughout the Community in terms of individual dietary advice and to regulators concerned with deciding policy relating to human diet and health.

Biomarker studies are clearly multidisciplinary in nature and transnational in their ultimate effect. A coherent approach can only arise therefore by considering the special requirements of individual regions arising from unique social factors and agricultural history while developing a European approach which is widely applicable and comparable between regions.

The production of a new series of reviews in the area of biomarkers and a register of experimental methods which have been critically evaluated by several of the participants will be of great value in attempting to prioritise and optimise approaches to biomarkers.

Coordinator

Ministry of Agriculture, Fisheries and Food
Address

NR4 7UQ Norwich
United Kingdom

Participants (15)

BBSRC Institute of Food Research
United Kingdom
Address
Norwich Research Park Colney Lane
NR4 7UA Norwich
COMMISSION OF THE EUROPEAN COMMUNITIES
Italy
Address
Via Enrico Fermi 1, Tp 460
21020 Barasso
I.N.R.A.
France
Address

63009 Clermont-ferrand Cedex 01
INSTITUTE OF NUTRITIONAL PHYSIOLOGY
Germany
Address

76131 Karlsruhe
MEDCON KONTRAKLABOR G.M.B.H.
Germany
Address

29664 Walsrode
NATIONAL FOOD ADMINISTRATION
Sweden
Address

751 26 Uppsala
NATIONAL FOOD AGENCY OF DENMARK
Denmark
Address

2860 Söborg
NATIONAL INSTITUTE OF RESEARCH FOR FOOD AND NUTRITION
Italy
Address
Via Ardeatina 546
00178 Roma
NATIONAL RESEARCH COUNCIL OF ITALY
Italy
Address
Viale Einaudi 51
70125 Bari
PAUL-EHRLICH INSTITUT
Germany
Address

63225 Langen
TNO
Netherlands
Address

3700 AJ Zeist
UNIVERSITY COLLEGE CORK
Ireland
Address

Cork
UNIVERSITY OF THESSALONIKI
Greece
Address

540 06 Thessaloniki
University of Helsinki
Finland
Address

00014 Helsinki
WAGENINGEN AGRICULTURAL UNIVERSITY
Netherlands
Address

6700 HB Wageningen