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DNA vaccines for aquaculture: Development and testing of plasmid vectors for vaccination against bacterial and viral fish pathogens.

Objective

The global objective is to further the development of DNA vaccine against fish pathogens for use by the aquaculture industry.

The specific objectives are:
1. To produce and test many different genes from vibriosis for their protective efficacy within DNA vaccines. This information will aid the development of DNA vaccines against many bacterial diseases.
2. To develop a DNA vaccine against bacterial kidney disease (BKD), a serious emerging disease for which there currently is no effective vaccine.
3. To develop methods to administer DNA vaccines by dip, immersion or oral delivery.
4. To evaluate the role of CpG immunostimulatory sequences for augmenting immune responses to DNA vaccines and develop CpG-optimized DNA vaccine vectors.
5. To measuring the kinetics of humoral and cell-mediated specific and non-specific immune responses to DNA vaccines and CpG motifs by use a cannulation system that allows repeated blood sampling from individual fish.
6. To determine certain safety aspects of DNA vaccines including (i) the kinetics and longevity of antigen expression, (ii) the persistence of plasmid in vaccinated host, and (iii) the risk of integration in the vaccinated fish.

Coordinator

QIAGEN GMBH
Address
4,Max-volmer-strasse 4
40724 Hilden
Germany

Participants (5)

INSTITUTE OF MARINE RESEARCH
Norway
Address

5392 Storeboe
INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA
Spain
Address
Carreteria De Algete A El Casar Km 8.1 S/n
28130 Valdeolmos - Madrid
UNIVERSITY OF ABERDEEN
United Kingdom
Address
Tillydrone Avenue 2
Aberdeen
Umea University
Sweden
Address

901 87 Umea
University of Plymouth
United Kingdom
Address
Drake Circus
PL4 8AA Plymouth