Objective
Canine infections by Leishmania infantum are extremely frequent in southern Europe, with prevalences of 5-7% of the total dog population. The reduction of infection rates in dogs is expected to lower the transmission in the natural reservoir, reducing the frequency of human exposure and eventually allowing the eradication of this life-threatening disease of dogs and humans. The response to chemotherapy is better when the dogs are diagnosed very early, procedure not available at present. Moreover, preliminary work seems to indicate that some dogs exposed to the parasite, in endemic areas, never develop the disease.
On these grounds, the project presented has two main objectives: development of an early diagnostic system and a vaccine for canine leishmaniasis. The development of a diagnostic kit will be accomplished through the identification and selection of antigens, in naturally and experimentally infected dogs, and the purification and/or cloning and expression of recombinant antigens. The development of a vaccine against canine leishmaniasis will start with the characterization of resistant dogs in endemic areas. This study, involving clinical, parasitological and immunological evaluations, will allow the identification of potentially protective antigens. Vaccination trials in dogs (mixed breed and pure breed animals) will be carried out with putative protective antigens purified (biochemically or from gen cloning) and DNA immunogens. After selection of immunization procedure, final phase of the project will include a field trial, in endemic areas, of the efficacy against a natural challenge by L. Infantum.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology immunisation
- natural sciences biological sciences genetics DNA
- agricultural sciences animal and dairy science domestic animals
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
28040 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.