Objective
Salmonellosis is one of the major cause of human disease related to food consumption. Poultry products are the main source of human toxi-infections, mostly because of asymptomatic carrier-state (i.e persistence of Salmonella in apparently healthy fowls several weeks after contamination or experimental inoculation). Most often the serotype responsible for human food poisoning is Salmonella enteritidis. Caecal and ovarian Salmonella carrierstate will be considered. The former results in horizontal transmission of the bacteria and leads to human disease through contamination of the egg shell at the oviposition and of the carcass during evisceration. The latter results in vertical transmission of Salmonella and in yolk contamination. It has been shown that resistance to Salmonella infection and carrier-state was partly genetically controlled. Major genes of resistance to infection have been identified whereas genes controlling resistance to carrier-state are still unknown. Our objectives are therefore:
1. To discover which genes control caecal carrier-state after inoculation with Salmonella enteritidis,
2. To find out to what extent these genes also control resistance to ovarian carrier state after inoculation with Salmonella enteritidis,
3. To study the mode of action of these genes to help in their identification and their use for selection. In the longer term (beyond the limits of this project) these results will be transferred (by comparative genetics) to other animal species also susceptible to Salmonella but which lend themselves less favourably to genetics studies. We shall first measure in a commercial poultry line the effects of the resistance genes already identified in mouse (TASK 1) or mapped in fowls when studying resistance to mortality (TASK 2). As genes controlling resistance to carrier-state and resistance to mortality partly differ, carrier state QTL mapping will be achieved in TASK 3 to discover other genome regions (or Quantitative Trait _oci) involved. In TASK 4 we shall identify the differences in host response to Salmonella enteritidis between genetically resistant and susceptible animals: this will lead us to understand the mode of action of these genes and will contribute to their identification. In TASK 5 we shall determine to which extent genetic resistance will be efficient against other Salmonella strains or serotypes. At the end of this project it will be known how to perform marker assisted selection for increased resistance to carrier-state and which advantag to expect from such a genetic improvement.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- agricultural sciences agricultural biotechnology marker assisted selection
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences genetics genomes
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Coordinator
37380 NOUZILLY
France
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