Objective
To advance our understanding of radiation carcinogenesis and to obtain information relevant to radiation protection and the management of patients with radiation induced thyroid tumours we propose to carry out an integrated study of morphological, cell and molecular biological and clinical aspects of thyroid tumours from patients exposed to high levels of fallout from the Chernobyl accident. We will utilise the unique resource of paired tumour/normal tissue samples from these patients, carry out the study in leading European centres, using novel techniques of cell cycle analysis, DNA chip technology, FISH and analysis of DNA repair mechanisms. These studies will be carried out on the same tumours and the results will be correlated with careful diagnosis, morphological analysis of the tumour samples and evidence of clinical outcome to provide a comprehensive study of the defects involved in radiation carcinogenesis and their relevance to diagnosis and tumour behaviour.
181 cases studied, morphological data completed on all and molecular biological data on ret completed on 162 assayable cases. RFG and mutant protein studies nearing completion. Microarray analysis completed on a subset of tumours - no differences observed between post Chernobyl cancers and those of non radiation aetiology. Rearrangements identified by FISH and correlated with RT-PCR data. Database complete and ready to undergo analysis for correlation with morphology and clinical presentation. Large dataset ready for transfer to the Chernobyl Tissue Bank for integration with other projects. 13 papers published, submitted or in press - more in preparation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences databases
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
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Coordinator
SA2 8PP SWANSEA
United Kingdom
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