Objective Ionising radiation induces a plethora of DNA non-double strand break lesions such as oxidised bases, a basic sites and single strand breaks. Strong evidence exists that ionising radiation induces, besides isolated DNA lesions; a unique form o f DNA damage termed clustered damage consisting of closely spaced lesions on opposite DNA strands. There is also evidence that repair of lesions within clustered damage sites is compromised compared with the effective repair of isolated lesions.We will investigate the following aspects of radiation-induced single and clustered DNA damage: (i) frequency and nature of the damage, (ii) mechanisms of repair, (iii) interference with transcription, replication and chromatin dynamics and (iv) biological consequences (stress responses, mutations, lethality). To achieve these goals we will exploit a variety of new technologies and utilise different organisms with defined mutations in damage response genes. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesgeneticsmutation Programme(s) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Topic(s) 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator LEIDEN UNIVERSITY EU contribution No data Address Wassenaarseweg 72 2300 RA LEIDEN Netherlands See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all COMMISSARIAT A L'ENERGIE ATOMIQUE France EU contribution No data Address Avenue du General Leclerc 60-68 92265 FONTENAY AUX ROSES See on map Total cost No data ERASMUS UNIVERSITEIT ROTTERDAM Netherlands EU contribution No data Address Dr. Molewaterplein 50 3000 DR ROTTERDAM See on map Total cost No data GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH Germany EU contribution No data Address Ingolstaedter Landstrasse 1 85764 OBERSCHLEISSHEIM See on map Total cost No data INSTITUT CURIE France EU contribution No data Address Rue d'Ulm 26 75248 PARIS See on map Total cost No data MEDICAL RESEARCH COUNCIL United Kingdom EU contribution No data Address Harwell OX11 0RD Didcot See on map Total cost No data UNIVERSITY OF SUSSEX United Kingdom EU contribution No data Address Falmer BN1 9RR BRIGHTON / FALMER See on map Total cost No data
